Year 2020 in review – Intensive care

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2. Young PJ, Bagshaw SM, Forbes AB, Nichol AD, Wright SE, Bailey M, et al. Effect of Stress Ulcer Prophylaxis with Proton Pump Inhibitors vs. Histamine-2 Receptor Blockers on In‑Hospital Mortality among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial. JAMA – Journal of the American Medical Association 2020; 323.

3. Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Schefold JC, et al. Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU. New England Journal of Medicine 2018; 379.

4. Chu DK, Kim LHY, Young PJ, Zamiri N, Almenawer SA, Jaeschke R, et al. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta‑analysis. The Lancet 2018; 391.

5. Conservative Oxygen Therapy during Mechanical Ventilation in the ICU. New England Journal of Medicine 2020; 382: 989–998. doi: 10.1056/NEJMoa1903297.

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9. Ricard JD, Roca O, Lemiale V, Corley A, Braunlich J, Jones P, et al. Use of nasal high flow oxygen during acute respiratory failure. Intensive Care Medicine 2020.

10. Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. New England Journal of Medicine 2019; 381.

11. Chang W, Sun Q, Peng F, Xie J, Qiu H, Yang Y. Validation of neuromuscular blocking agent use in acute respiratory distress syndrome: A meta‑analysis of randomized trials. Critical Care 2020; 24.

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13. Ferrando C, Mellado‑Artigas R, Gea A, Arruti E, Aldecoa C, Adalia R, et al. Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high‑flow nasal oxygen therapy: A multicenter, adjusted cohort study. Critical Care 2020; 24.

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17. Gershengorn HB, Stelfox HT, Niven DJ, Wunsch H. Association of Premorbid Blood Pressure with Vasopressor Infusion Duration in Patients with Shock. American journal of respiratory and critical care medicine 2020; 202.

18. Burstein B, Tabi M, Barsness GW, Bell MR, Kashani K, Jentzer JC. Association between mean arterial pressure during the first 24 hours and hospital mortality in patients with cardiogenic shock. Critical Care 2020; 24.

19. Panwar R, Tarvade S, Lanyon N, Saxena M, Bush D, Hardie M, et al. Relative Hypotension and Adverse Kidney‑related Outcomes among Critically Ill Patients with Shock. A Multicenter, Prospective Cohort Study. American Journal of Respiratory and Critical Care Medicine 2020; 202.

20. Lamontagne F, Richards‑Belle A, Thomas K, Harrison DA, Sadique MZ, Grieve RD, et al. Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients with Vasodilatory Hypotension: A Randomized Clinical Trial. JAMA – Journal of the American Medical Association 2020; 323.

21. Saugel B, Kouz K, Meidert AS, Schulte‑Uentrop L, Romagnoli S. How to measure blood pressure using an arterial catheter: A systematic 5-step approach. Critical Care 2020; 24.

22. Chen JT, Roberts R, Fazzari MJ, Kashani K, Qadir N, Cairns CB, et al. Variation in fluid and vasopressor use in shock with and without physiologic assessment: A multicenter observational study. Critical Care Medicine 2020.

23. Meyhoff TS, Møller MH, Hjortrup PB, Cronhjort M, Perner A, Wetterslev J. Lower vs. Higher Fluid Volumes During Initial Management of Sepsis: A Systematic Review With Meta‑Analysis and Trial Sequential Analysis. Chest 2020; 157.

24. Roberts RJ, Miano TA, Hammond DA, Patel GP, Chen JT, Phillips KM, et al. Evaluation of vasopressor exposure and mortality in patients with septic shock. Critical Care Medicine 2020.

25. Zdolsek M, Hahn RG, Sjöberg F, Zdolsek JH. Plasma volume expansion and capillary leakage of 20% albumin in burned patients and volunteers. Critical Care 2020; 24.

26. dos Santos EC, Orbegozo D, Mongkolpun W, Galfo V, Nan W, Bogossian EG, et al. Systematic review and meta‑analysis of effects of transfusion on hemodynamic and oxygenation variables. Critical Care Medicine 2020.

27. Guinot PG, Nguyen M, Duclos V, Soudry‑Faure A, Bouhemad B, Guinot PG, et al. Oral water ingestion in the treatment of shock patients: a prospective randomized study. Intensive Care Medicine 2020; 46.

28. Li Y, Li H, Zhang D. Timing of norepinephrine initiation in patients with septic shock: A systematic review and meta‑analysis. Critical Care 2020; 24.

29. Pancaro C, Shah N, Pasma W, Saager L, Cassidy R, van Klei W, et al. Risk of Major Complications after Perioperative Norepinephrine Infusion through Peripheral Intravenous Lines in a Multicenter Study. Anesthesia and Analgesia 2020.

30. Tran QK, Mester G, Bzhilyanskaya V, Afridi LZ, Andhavarapu S, Alam Z, et al. Complication of vasopressor infusion through peripheral venous catheter: A systematic review and meta‑analysis. American Journal of Emergency Medicine 2020.

31. Belletti A, Nagy A, Sartorelli M, Mucchetti M, Putzu A, Sartini C, et al. Effect of continuous epinephrine infusion on survival in critically ill patients: A meta‑analysis of randomized trials. Critical Care Medicine 2020.

32. Aso S, Matsui H, Fushimi K, Yasunaga H. Vasopressin versus epinephrine as adjunct vasopressors for septic shock. Intensive Care Medicine 2020; 46.

33. Silversides JA, McAuley DF, Blackwood B, Fan E, Ferguson AJ, Marshall JC. Fluid management and deresuscitation practices: A survey of critical care physicians. Journal of the Intensive Care Society 2020; 21.

34. Wu Z, Zhang S, Xu J, Xie J, Huang L, Huang Y, et al. Norepinephrine vs. Vasopressin: Which Vasopressor Should Be Discontinued First in Septic Shock? A Meta‑Analysis. Shock 2020; 53.

35. Santer P, Anstey MH, Patrocínio MD, Wibrow B, Teja B, Shay D, et al. Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial. Intensive Care Medicine 2020; 46.

36. Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before‑After Study. Chest 2017; 151.

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42. Miyamoto Y, Aso S, Iwagami M, Yasunaga H, Matsui H, Fushimi K, et al. Association between IV Thiamine and Mortality in Patients with Septic Shock: A Nationwide Observational Study. Critical Care Medicine 2020; 48.

43. Hwang SY, Ryoo SM, Park JE, Jo YH, Jang DH, Suh GJ, et al. Combination therapy of vitamin C and thiamine for septic shock: a multi‑ centre, double‑blinded randomized, controlled study. Intensive Care Medicine 2020; 46.

44. Vail EA, Wunsch H, Pinto R, Bosch NA, Walkey AJ, Lindenauer PK, et al. Use of Hydrocortisone, Ascorbic Acid, and Thiamine in Adults with Septic Shock. American Journal of Respiratory and Critical Care Medicine 2020.

45. Kapur J, Elm J, Chamberlain JM, Barsan W, Cloyd J, Lowenstein D, et al. Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. New England Journal of Medicine 2019; 381.

46. Rossetti AO, Schindler K, Sutter R, Rüegg S, Zubler F, Novy J, et al. Continuous vs. Routine Electroencephalogram in Critically Ill Adults with Altered Consciousness and No Recent Seizure: A Multicenter Randomized Clinical Trial. JAMA Neurology 2020; 77.

47. Anderson D, Jirsch JD, Wheatley MB, Brindley PG. Electroencephalogram patterns in critical care: A primer for acute care doctors. Journal of the Intensive Care Society 2020.

48. Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, et al. The CRASH-2 trial: A randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technology Assessment 2013; 17.

49. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo‑controlled trial. The Lancet 2019; 394.

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51. Chen H, Wu F, Yang P, Shao J, Chen Q, Zheng R. A meta‑analysis of the effects of therapeutic hypothermia in adult patients with traumatic brain injury. Critical Care 2019; 23.

52. Cooper DJMD, Nichol ADMBP, Bailey MP, Bernard SMMD, Cameron PAMD, Pili‑Floury SMDP, et al. Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial: The Journal of the American Medical Association. JAMA 2018; 320.

53. Hawryluk GWJ, Aguilera S, Buki A, Bulger E, Citerio G, Cooper DJ, et al. A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC). In: Intensive Care Medicine 2019.

54. Cook AM, Morgan Jones G, Hawryluk GWJ, Mailloux P, McLaughlin D, Papangelou A, et al. Guidelines for the Acute Treatment of Cerebral Edema in Neurocritical Care Patients. Neurocritical Care 2020; 32.

55. Sandroni C, D’Arrigo S, Cacciola S, Hoedemaekers CWE, Kamps MJA, Oddo M, et al. Prediction of poor neurological outcome in comatose survivors of cardiac arrest: a systematic review. Intensive Care Medicine 2020; 46.

56. Greer DM, Shemie SD, Lewis A, Torrance S, Varelas P, Goldenberg FD, et al. Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project. JAMA – Journal of the American Medical Association 2020; 324.

57. Hayek SS, Leaf DE, Samman Tahhan A, Raad M, Sharma S, Waikar SS, et al. Soluble Urokinase Receptor and Acute Kidney Injury. New England Journal of Medicine. 2020; 382.

58. Tacke F. Risk Prediction for Acute Kidney Injury – Super Important, Now suPAR Easy? New England Journal of Medicine 2020; 382.

59. Darmon M, Bourmaud A, Reynaud M, Rouleau S, Meziani F, Boivin A, et al. Performance of Doppler‑based resistive index and semi‑quantitative renal perfusion in predicting persistent AKI: results of a prospective multicenter study. Intensive Care Medicine 2018; 44.

60. Garnier F, Daubin D, Larcher R, Bargnoux AS, Platon L, Brunot V, et al. Reversibility of Acute Kidney Injury in Medical ICU Patients: Predictability Performance of Urinary Tissue Inhibitor of Metalloproteinase-2 x Insulin‑Like Growth Factor‑Binding Protein 7 and Renal Resistive Index. Critical Care Medicine 2020.

61. Zarbock A, Kellum JA, Schmidt C, van Aken H, Wempe C, Pavenstädt H, et al. Effect of early vs. delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: The elain randomized clinical trial. JAMA – Journal of the American Medical Association 2016; 315.

62. Gaudry S, Hajage D, Schortgen F, Martin‑Lefevre L, Pons B, Boulet E, et al. Initiation Strategies for Renal‑Replacement Therapy in the Intensive Care Unit. New England Journal of Medicine 2016; 375.

63. Barbar SD, Clere‑Jehl R, Bourredjem A, Hernu R, Montini F, Bruyère R, et al. Timing of Renal‑Replacement Therapy in Patients with Acute Kidney Injury and Sepsis. New England Journal of Medicine 2018.

64. Bagshaw SM, Wald R, Adhikari NKJ, Bellomo R, da Costa BR, Dreyfuss D, et al. Timing of initiation of renal‑replacement therapy in acute kidney injury. New England Journal of Medicine 2020; 383.

65. Walsh M, Merkel PA, Peh C‑A, Szpirt WM, Puéchal X, Fujimoto S, et al. Plasma Exchange and Glucocorticoids in Severe ANCA‑Associated Vasculitis. New England Journal of Medicine 2020; 382.

66. Zarbock A, Küllmar M, Kindgen‑Milles D, Wempe C, Gerss J, Brandenburger T, et al. Effect of Regional Citrate Anticoagulation vs. Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury. JAMA 2020; 324.

67. Alberici F, Delbarba E, Manenti C, Econimo L, Valerio F, Pola A, et al. A single center observational study of the clinical characteristics and short‑term outcome of 20 kidney transplant patients admitted for SARS‑CoV2 pneumonia. Kidney International 2020; 97.

68. Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, et al. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nature Reviews Nephrology 2020.

69. Clark EG, Hiremath S, McIntyre L, Wald R, Hundemer GL, Joannidis M. Haemoperfusion should only be used for COVID-19 in the context of randomized trials. Nature Reviews Nephrology 2020.

70. Horák J, Chvojka J, Tégl V, Nalos L, Peltanová M, Beneš J, et al. Hemadsorpční metody u kriticky nemocných – dvojitá sázka naslepo? Anest intenziv Med 2020; 31(4): 172–175.

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72. Seymour CW, Kennedy JN, Wang S, Chang CCH, Elliott CF, Xu Z, et al. Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis. In: JAMA – Journal of the American Medical Association 2019.

73. Rhee C, Kadri SS, Danner RL, Suffredini AF, Massaro AF, Kitch BT, et al. Diagnosing sepsis is subjective and highly variable: A survey of intensivists using case vignettes. Critical Care 2016; 20.

74. Horak J, Martinkova V, Radej J, Matejovič M. Back to Basics: Recognition of Sepsis with New Definition. Journal of Clinical Medicine 2019; 8.

75. Waligora G, Gaddis G, Church A, Mills L. Rapid Systematic Review: The Appropriate Use of Quick Sequential Organ Failure Assessment (qSOFA) in the Emergency Department. Journal of Emergency Medicine 2020.

76. Hernández G, Ospina‑Tascón GA, Damiani LP, Estenssoro E, Dubin A, Hurtado J, et al. Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs. Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA‑SHOCK Randomized Clinical Trial. JAMA 2019; 321: 654–664. doi:10.1001/jama.2019.0071.

77. Hernández G, Kattan E, Ospina‑Tascón G, Bakker J, Castro R. Capillary refill time status could identify different clinical phenotypes among septic shock patients fulfilling Sepsis-3 criteria: a post hoc analysis of ANDROMEDA‑SHOCK trial. Intensive Care Medicine 2020; 46.

78. Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G, Bettio M, et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. European Journal of Cancer 2018; 103.

79. Allemani C, Matsuda T, di Carlo V, Harewood R, Matz M, Nikšić M, et al. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population‑based registries in 71 countries. The Lancet 2018; 391.

80. Spika D, Bannon F, Bonaventure A, Woods LM, Harewood R, Carreira H, et al. Life tables for global surveillance of cancer survival (the CONCORD programme): Data sources and methods. BMC Cancer 2017; 17.

81. Karvunidis T, Lysák D, Matějovič M. Dospělý onkologický nemocný v intenzivní péči. Je již čas říci „ano, zvážíme to“než říkat „ne“?! Anest intenziv Med. 2017; 28.

82. Azoulay E, Schellongowski P, Darmon M, Bauer PR, Benoit D, Depuydt P, et al. The Intensive Care Medicine research agenda on critically ill oncology and hematology patients. Intensive Care Medicine 2017; 43.

83. Kroschinsky F, Stölzel F, von Bonin S, Beutel G, Kochanek M, Kiehl M, et al. New drugs, new toxicities: Severe side effects of modern targeted and immunotherapy of cancer and their management. Critical Care 2017; 21.

84. Azoulay E, Darmon M, Valade S. Acute life‑threatening toxicity from CAR T‑ cell therapy. Intensive Care Medicine 2020; 46.

85. Fessas P, Possamai LA, Clark J, Daniels E, Gudd C, Mullish BH, et al. Immunotoxicity from checkpoint inhibitor therapy: clinical features and underlying mechanisms. Immunology 2020; 159.

86. Assoun S, Lemiale V, Azoulay E. Molecular targeted therapy‑related life‑threatening toxicity in patients with malignancies. A systematic review of published cases. Intensive Care Medicine 2019; 45.

87. Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V. Acute respiratory failure in immunocompromised adults. The Lancet Respiratory Medicine 2019; 7.

88. Munshi L, Darmon M, Soares M, Pickkers P, Bauer P, Meert A‑P, et al. Acute Respiratory Failure Outcomes in Patients with Hematologic Malignancies and Hematopoietic Cell Transplant: A Secondary Analysis of the EFRAIM Study. Biology of Blood and Marrow Transplantation 2020.

89. Azoulay E, Russell L, van de Louw A, Metaxa V, Bauer P, Povoa P, et al. Diagnosis of severe respiratory infections in immunocompromised patients. Intensive Care Medicine 2020; 46.

90. Messika J, Darmon M, Mal H, Pickkers P, Soares M, Canet E, et al. Etiologies and Outcomes of Acute Respiratory Failure in Solid Organ Transplant Recipients: Insight Into the EFRAIM Multicenter Cohort. Transplantation Proceedings 2020.

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92. Frat JP, Coudroy R, Marjanovic N, Thille AW. High‑flow nasal oxygen therapy and noninvasive ventilation in the management of acute hypoxemic respiratory failure. Annals of Translational Medicine 2017; 5.

93. Coudroy R, Pham T, Boissier F, Robert R, Frat JP, Thille AW. Is immunosuppression status a risk factor for noninvasive ventilation failure in patients with acute hypoxemic respiratory failure? A post hoc matched analysis. Annals of Intensive Care 2019; 9.

94. Lemiale V, de Jong A, Dumas G, Demoule A, Mokart D, Pène F, et al. Oxygenation Strategy during Acute Respiratory Failure in Critically‑ Ill Immunocompromised Patients. Critical Care Medicine 2020.

95. Demoule A, Antonelli M, Schellongowski P, Pickkers P, Soares M, Meyhoff T, et al. Respiratory Mechanics and Outcomes in Immunocompromised Patients With ARDS. Chest 2020.