What is the role of nutriceuticals in dyslipidemia management? Armolipid Plus

Česká verzia

Authors: Hana Rosolová ^1,2
Authors place of work: Centrum preventivní kardiologie LF v Plzni UK ¹; II. interní klinika LF v Plzni UK a FN Plzeň ²
Published in the journal: AtheroRev 2017; 2(2): 143-146
Category: reviews

Summary

Low density lipoprotein-cholesterol (LDL-C) reduction is the basic approach in the treatment and prevention of cardiovascular disease on the atherosclerosis background. Except of healthy life style, nutriceuticals are possible to recommend for atherogenic lipid profile influencing, e.g. Armolipid Plus. Results of Armolipid Plus clinical studies are presented; this nutriceutical reduces LDL-C by 15–30 % and glucose level. Armolipid Plus changed the size and density of LDL particles from small dense to big normodense less atherogenic particles in patients with familial combined hyperlipoproteinemia. This nutriceutical improved endothelial dysfunction and reduced pulse wave velocity. Armolipid Plus is possible to indicate in combination with lipid modifying drugs or itself within healthy life style.

Key words:
nutriceuticals, dyslipidemia, lipid modifying drugs

Zdroje

1. Baigent C, Blackwell L, Emberson J et al. [Cholesterol Treatment Trialists’ (CTT) Collaboration]. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta- analysis of data from 170,000 participants in 26 randomised trials. Lancet 2010; 376(9753): 1670–1681. Dostupné z DOI: <http://dx.doi.org/10.1016/S0140–6736(10)61350–5>.

2. Cannon CP, Blazing MA, Giugliano RP et al. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med 2015; 372(25): 2387–2397. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1410489>.

3. Sabatine MS, Giugliano RP, Keech AC et al. Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med 2017; 376(18): 1713–1722. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1615664>.

4. Catapano AL, Graham I, De Backer G et al. 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. The Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS). Eur Heart J 2016; 37 (39): 2999–3058. Dostupné z DOI: <http://dx.doi.org/10.1093/eurheartj/ehw272>.

5. Collins R, Armitage J, Parish S et al. [Heart Protection Study Collaborative Group]. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: A randomised placebo-controlled trial. Lancet 2003; 361(9374): 2005–2016.

6. Affuso F, Ruvolo A, Micillo F et al. Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study. Nutr Metab Cardiovasc Dis 2010; 20(9): 656–661.

7. Pirro M, Del Giorno R, Lupattelli G et al. Nutraceutical combination (red yeast rice, berberine and policosanols) improves aortic stiffness in low-moderate risk hypercholesterolemic patients. PharmaNutrition 2013;1(2):73–77. Dostupné z WWW: <https://www.researchgate.net/publication/271001602_Nutraceutical_combination_red_yeast_rice_berberine_and_policosanols_improves_aortic_stiffness_in_low-moderate_risk_hypercholesterolemic_patients>.

8. Ruscica M, Gomaraschi M, Mombelli G et al. Nutraceutical approach to moderate cardiometabolic risk: results of a randomized, double-blind and crossover study with Armolipid Plus. J Clin Lipidol 2014; 8(1): 61–68. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jacl.2013.11.003>.

9. Sola R, Valls RM, Puzo J et al. Effects of poly-bioactive compounds on lipid profile and body weight in a moderately hypercholesterolemic population with low cardiovascular disease risk: a multicenter randomized trial. PLoS One 2014; 9(8): e101978. Dostupne z DOI: <http://dx.doi.org/10.1371/journal.pone.0101978>.

10. Gonnelli S, Caffarelli C, Stolakis K et al. Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Rice, Policosanols, and Berberine) in Patients with Low-Moderate Risk Hypercholesterolemia: A Double-Blind, Placebo-Controlled Study. Curr Ther Res Clin Exp 2014; 77: 1–6. Dostupné z DOI: <http://dx.doi.org/10.1016/j.curtheres.2014.07.003>.

11. Pisciotta L, Bellocchio A, Bertolini S. Nutraceutical pill containing berberine versus ezetimibe on plasma lipid pattern in hypercholesterolemic subjects and its additive effect in patients with familial hypercholesterolemia on stable cholesterol lowering treatment. Lipids Health Dis 2012;11:123. Dostupné z DOI: <http://dx.doi.org/10.1186/1476–511X-11–123>.

12. Pirro M, Mannarino MR, Bianconi V et al. The effects of nutraceutical combination on plasma lipids and glucose: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 2016; 110: 76–88. Dostupné z DOI: <http://dx.doi.org/10.1016/j.phrs.2016.04.021>.

13. Hopkins PN, Heiss G, Ellison RC et al. Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case–control comparison from the nNational Heart, Lung, and Blood Institute Family Heart Study. Circulation 2003; 108(5): 519–523.

14. Gentile M, Calcaterra I, Strazzullo A et al. Effects of Armolipid Plus on small dense LDL particles in a sample of patients affected by familial combined hyperlipidemia. Clin Lipidol 2015; 10(6): 475–480. Dostupné z DOI: <http://dx.doi.org/10.2217/clp.15.37>.

15. Affuso F, Ruvolo A, Micillo F et al. Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study. Nutr Metab Cardiovasc Dis 2010; 20(9): 656–661. Dostupné z DOI: <http://dx.doi.org/10.1016/j.numecd.2009.05.017>.

16. Pirro M, Lupattelli G, Del Giorno R et al. Nutraceutical combination (red yeast rice, berberine and policosanols) improves aortic stiffness in low-moderate risk hypercholesterolemic patients. PharmaNutrition 2013; 1(2):73–77.