BENEDICT – BErgamo NEphrologic DIabetic Complications Trial
Authors:
prof. MUDr. Jindřich Špinar, CSc.; Fesc 1; Prof. MUDr. Jiří Vítovec, CSc.; Fesc 2
Authors place of work:
Interní kardiologická klinika, FN Brno-Bohunice
1; I. interní kardioangiologická klinika
FN U sv. Anny, Brno
2
Published in the journal:
Kardiol Rev Int Med 2005, 7(4): 201-204
Category:
Editorial
Summary
BENEDICT study- BErgamo NEphrologic DIabetic Complications Trial- was aimed at the prevention and the control of microalbuminuria in hypertonics – II type diabetics with normal renal functions. Persistent microalbuminuria developed at 17 of 300 patients treated with the combination of trandolapril + verapamil (5,7 %), at 30 of 300 patients treated with placebo (10,0 %), at 18 of 301 patients treated only with trandolapril (6,0 %) and at 36 of 303 patients (11,9 %) (all < 0,01 trandolapril vs placebo and ns placebo vs verapamil). Combination treatment trandolapril + verapamil significantly decreased the occurence of microalbuminuria at the patients with hypertension and diabetes mellitus in comparison with placebo. Trandolapril alone decreased the occurrence of microalbuminuria, while verapamil had no effect in this way. At the patients with hypertension, diabetes mellitus and normal renal functions, ACE‑inhibitors are the choice drug for blood pressure control.
Key words:
diabetes mellitus - hypertension – microalbuminuria – trandolapril - verapamil
Zdroje
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Štítky
Paediatric cardiology Internal medicine Cardiac surgery CardiologyČlánok vyšiel v časopise
Cardiology Review
2005 Číslo 4
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