Dual anti-aggregation therapy in the prevention cerebral infarction
Authors:
Goldemund; R. Mikulík
Authors place of work:
I. neurologická klinika LF MU a FN u sv. Anny, Brno
Published in the journal:
Kardiol Rev Int Med 2007, 9(2): 120-123
Category:
Editorial
Summary
Dual anti-aggregation therapy in the prevention cerebral infarction. Ischemic cerebrovascular accidents (CVA) are injuries with a high rate of occurrence. According to information in the IKTA database of 2000, the rate of occurrence of cerebral infarction or transitory ischemic attacks is 250 per 100 000 inhabitants. For 90 days following a transitory ischemic attack, a patient has a 10% risk of another ischemic CVA. There is 7.4% risk that a patient with cerebral infarction will suffer recurrent cerebral infarction within 90 days, and a 40% chance within 5 years. The objective of anti-aggregation therapy is to prevent recurrence of the events, though the effect of traditional treatment with acetylsalicylic acid and thienopyridine derivatives (ticlopidin, clopidogrel) is relatively low (e.g. ASA produces an annual reduction in absolute risk of around 1%). The text summarizes recent experience with dual anti-aggregation therapy, based on the recently published MATCH, CHARISMA and ESPRIT studies.
Keywords:
cerebral infarction – anti-aggregation – prevention – dual anti-aggregation therapy
Zdroje
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Štítky
Paediatric cardiology Internal medicine Cardiac surgery CardiologyČlánok vyšiel v časopise
Cardiology Review
2007 Číslo 2
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