#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Comparison of differences between male and female patients with acute myocardial infarction


Authors: A. Tomášek 1;  S. Janoušek 1;  R. Adámková 1;  J. Tůmová 2;  Z. Čermáková 2;  J. Špinar 1
Authors place of work: Interní kardiologická klinika FN Brno 1;  Oddělení klinické biochemie FN Brno 2
Published in the journal: Kardiol Rev Int Med 2008, 10(3): 96-101

Summary

We studied the correlation between gender, clinical course, treatment methods and prognosis in patients with acute myocardial infarction admitted to the coronary care unit during a period of 2 years. Women accounted for only 35,5 % of the total of 889 patients, they were on average 7 years older than men, had a higher incidence of hypertension, diabetes or chronic angina pectoris, and presented more often with heart failure and atrial fibrillation. A statistically nonsignificant trend to less frequent use of coronarography or intervention methods was observed in women. During hospitalization, women were at a higher risk of acute he art or respiratory failure, the incidence of life- threatening bradycardias or cardiopulmonary resuscitati on. Their in‑hospital mortality was statistically higher than that of men, but there were no differences in long‑term mortality. There seems to be a significant link between women’s prognosis and their higher mean age and the related higher co-morbidity. These factors influence the use of catheterization diagnostic or treatment methods which have major implications for further prognosis of female patients.

Key words:
acute myocardial infarction – gender differences – prognosis


Zdroje

1. Rosamond W, Flegal K, Furi e K et al. He art Dise ase and Stroke Statistics – 2008 Update: A Report From the American He art Association Statistics Committee and Stroke Statistics Subcommittee. Circulati on 2008; 117: e25– e146.

2. Diamond GA, Forrester JS. Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. N Engl J Med 1979; 300: 1350– 1358.

3. Žák A. Estrogeny. In: Aschermann M (ed). Kardiologie. Praha: Galén 2004: 523– 530.

4. Zucker RD, Griffi th JL, Beshansky JR et al. Presentations of Acute Myocardial Infarction in Men and Women. J Gen Intern Med 1997; 12: 79– 87.

5. McSweeney JC, Cody M, O‘Sullivan P et al. Women’s Early Warning Symptoms of Acute Myocardial Infarction. Circulation 2003; 108: 2619– 2623.

6. Cheng CI, Yeh KH, Chang HW et al. Comparison of baseline characteristics, clinical features, angiographic results, and early outcomes in men vs women with acute myocardial infarction undergoing primary coronary intervention. Chest 2004; 126: 47– 53.

7. Goldberg RJ, Steg PG, Sadiq I et al. Extent of, and factors associated with, delay to hospital presentation in patients with acute coronary disease (the GRACE registry). Am J Cardi ol 2002; 89: 791– 796.

8. Kannel WB, Abbott RD. Incidence and prognosis of unrecognized myocardi al infarcti on. An update on the Framingham

study. N Engl J Med 1984; 311: 1144– 1147.

9. McSweeney JC, Cody M, O‘Sullivan P et al. Women’s Early Warning Symptoms of Acute Myocardial Infarction. Circulati on 2003; 108: 2619– 2623.

10. Canto JG, Shlipak MG, Rogers WJ et al. Prevalence, clinical characteristics and mortality among patients with myocardi al infarction presenting without chest pain. JAMA 2000; 283: 3223– 3229.

11. Gan SC, Beaver SK, Ho uck PM et al. Treatment of acute myocardial infarction and 30-day mortality among women and men. N Engl J Med 2000; 343: 8– 15.

12. Rathore SS, Berger AK, Weinfurt KP et al. Acute myocardial infarction complicated by atrial fibrillation in the elderly: prevalence and outcomes. Circulation 2000; 101: 969– 974.

13. Kannel WB. Metabolic risk factors for coronary heart disease in women: Perspectives from the Framingham study. Am He art J 1987; 114: 413– 429.

14. Barrett-Connor EL, Cohn BA, Wingard DL et al. Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study. JAMA 1991; 265: 627– 631.

15. Maynard C, Beshansky JR, Griffi th JL et al. Influence of sex on the use of cardiac procedures in patients presenting to the emergency department. A prospective multicenter study. Circulation 1996; 94: SII93– SII98.

16. Ayanian JZ, Epstein AM. Differences in the use of procedures between women and men hospitalized for coronary he art disease. N Engl J Med 1991; 325: 221– 225.

17. Kornowski R, Lansky AJ, Mintz GS et al. Comparison of men versus women in cross-sectional are a luminal narrowing, quantity of plaque, presence of calcium in plaque, and lumen location in coronary arteries by intravascular ultraso und in patients with stable angina pectoris. Am J Cardi ol 1997; 79: 1601– 1605.

18. Little WC, Applegate RJ. Coronary angiography before myocardial infarction: Can the culprit site be prospectively recognized? Am Heart J 1998; 136: 368– 370.

19. Mehili J, Kastrati A, Dirschinger J et al. Differences in Prognostic Factors and Outcomes between women and men undergoing coronary artery stenting. JAMA 2000; 284: 1799– 1805.

20. Burke AP, Farb A, Malcom GT et al. Effect of Risk Factors on the Mechanism of Acute Thrombosis and Sudden Coronary De ath in Women. Circulation 1998; 97: 2110– 2116.

21. Guru V, Fremes SE, Austin PC et al. Gender Differences in Outcomes After Hospital Discharge From Coronary Artery Bypass Grafting. Circulation 2006; 113: 507– 516.

22. Wenger NK. Clinical characteristics of coronary heart disease in women: emphasis on gender differences. Cardiovasc Res 2002; 53: 558– 567.

23. Glasser R, Herrmann HC, Murphy SA et al. Benefit of an early invasive management strategy in women with acute coronary syndromes. JAMA 2002; 288: 3124– 3129.

24. Stone GW, Marcovitz P, Lansky AJ et al. Differential effects of stenting and angioplasty in women versus men undergoing a primary mechanical reperfusion strategy in acute myocardial infarction – the PAMI stent randomized trial. J Am Coll Cardi ol 1999; 33: 357A. Abstract 832– 836.

25. Vaccarino V, Parsons L, Every NR et al. Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants. N Engl J Med 1999; 341: 217– 225.

26. Maynard C, Every NR, Martin JS et al. Association of gender and survival in patients with acute myocardial infarction. Arch Intern Med 1997; 157: 1379– 1384.

27. Tunstall-Pedoe H, Morrison C, Woodward M et al. Sex differences in myocardial infarction and coronary deaths in the Scottish MONICA population of Glasgow 1985 to 1991: presentation, diagnosis, treatment, and 28- day case fatality of 3,991 events in men and 1,551 events in women. Circulation 1996; 93: 1981– 1992.

28. Vaccarino V, Krumholz VM, Yarzebski J et al. Sex differences in 2- year mortality after hospital discharge for myocardial infarction. Ann Intern Med 2001; 134: 173– 181.

29. MacIntyre K, Stewart S, Capewell S et al. Gender and survival: a population-based study of 201,114 men and women following a first acute myocardial infarction. J Am Coll Cardi ol 2001; 38: 729– 735.

30. Orenci a A, Bailey K, Yawn BP et al. Effect of gender on long-term outcome of angina pectoris and myocardial infarction/ sudden unexpected death. JAMA 1993; 269: 2392– 2402.

31. Sempos CT, Cleeman JI, Carroll MD et al. Prevalence of high blood cholesterol among US adults: An update based on guidelines from the Second Report of the Nati onal Cholesterol Education Program Adult Treatment Panel. JAMA 1993; 269: 3009– 3014.

32. McLaughlin TJ, Soumerai SB, Willison DJ et al. Adherence to national guidelines for drug treatment of suspected acute myocardial infarction: evidence for undertreatment in women and the elderly. Arch Intern Med 1996; 156: 799– 805.

33. Grant AO, Jacobs AK, Clancy C. Cardiovascular disease in women: are there solutions? Circulation 2004; 109: 561.

34. Špinar J, Vítovec J. Pacienti po infarktu nechtějí být zdraví. Cor Vasa 2007; 49: 443– 444.

35. Eagle KA, Kline-Rogers E, Goodman SG et al. Adherence to evidence-based therapies after discharge for acute coronary syndromes: an ongoing prospective, observational study. Am J Med 2004; 117: 73– 81.

36. Greenland P, Reicher- Reiss H, Goldbo urt U et al. In- hospital and 1- year mortality in 1,524 women after

myocardial infarction: Comparison with 4,315 men. Circulation 1991; 83: 484– 491.

37. Hendel RC. Myocardial infarction in women. Cardiology 1990; 77: S41– S57.

38. American Heart Association. 2001 Heart and Stroke Statistical Update. Dallas, TX: American He art Association 2000.

39. Wingard DL, Suarez L, Barrett- Connor E. The sex differential in mortality from all causes and ischemic heart disease. Am J Epidemi ol 1983; 117: 165– 172.

40. MacIntyre K, Stewart S, Capewell S et al. Gender and survival: a population-based study of 201,114 men and women following a first acute myocardial infarction. J Am Coll Cardi ol 2001; 38: 729– 735.

41. Marrugat J, Sala J, Masi a R et al. Mortality differences between men and women following first myocardial infarction. RESCATE Investigators. Recursos Empleados en el Sindrome Coronari o Agudo y Tiempo de Espera. JAMA 1998; 280: 1405– 1409.

Štítky
Paediatric cardiology Internal medicine Cardiac surgery Cardiology
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#