Beta-blockers with the smallest negative impact on cardiorespiratory fitness in healthy people

Česká verzia

Authors: E. Sovová; L. Štégnerová; M. Sovová; M. Koudelka; D. Tučková; R. Jochcová; M. Klugar
Authors place of work: Klinika tělovýchovného lékařství a kardiovaskulární rehabilitace LF UP a FN Olomouc I. interní klinika – kardiologická LF UP a FN Olomouc
Published in the journal: Kardiol Rev Int Med 2016, 18(3): 199-202

Summary

Physical activity belongs to the basic preventive and therapeutic methods in cardiology. A correct setup of physical activity is the base for better patient compliance and a better therapeutic effect. However, certain drugs can affect patients’ physical ability and performance. This applies especially to beta-blockers, which are used in patients with ischaemic heart disease, hypertension, heart failure and other diseases. The aim of this literary review was to find which beta-blockers (or their forms) have the smallest negative effect on cardiorespiratory fitness in healthy patients.

Methods:
The review question “Which beta-blockers have the smallest negative effect on cardiorespiratory ability in healthy patients?” was created using the PICO instrument and the keywords in PICO were used for the search strategy, corrected according to medical terms and thesaurus used in the databases. The search was done in May 2015 in databases Ovid Medline, Embase and Cinahl. The relevance of the studies was assessed by two independent reviewers.

Results:
842 studies were found in Ovid MedLine, 1174 in Embase and 5 in Cinahl (a total of 2021). A total of 417 duplicated studies were excluded. We found 5 relevant studies comparing the effect of administration of at least 2 different beta-blockers on the respiratory stress test in 64 healthy persons. Only 1 of these studies assessed the influence of beta-blockers on the maximum (peak) oxygen consumption.

Conclusion:
According to the reviewed studies, carvedilol and nebivolol were showed to have the best combination of properties with the lowest influence on the cardiorespiratory ability in healthy patients.

Keywords:
beta-blockers – physical activity – affecting of cardiorespiratory fitness

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