Late consequences of cardiotoxicity

Česká verzia

Authors: L. Elbl
Authors place of work: Privátní kardiologická ambulance, Brno
Published in the journal: Kardiol Rev Int Med 2017, 19(1): 22-29

Summary

Advances in oncological treatment have led to improved survival of patients with cancer, but have also increased morbidity and mortality due to the treatment side effects. Cardiovascular diseases are among the most frequent of these side effects, and there is a growing concern that they may lead to premature morbidity and death among cancer survivors. This may be caused by cardiotoxicity, which involves the direct effects of cancer treatment on heart function and structure, or by accelerated development of cardiovascular diseases, especially in the presence of traditional cardiovascular risk factors. The most common side effects of anti-cancer treatment include vasospastic and thromboembolic ischaemia, arterial hypertension, arrhythmia, and cardiac dysfunctions that may lead to heart failure. Although the issues related to cardio-oncology have received increasing attention in recent years, many aspects of both radiation-induced and cancer drug-induced cardiovascular disease remain to be fully elucidated. Furthermore, the inability to predict the long-term consequences of cardiovascular side effects of cancer treatment leads to under- or over-diagnosis of cardiovascular diseases, sometimes resulting in the failure to prevent adverse events and sometimes leading to inappropriate interruption of a potentially life-saving cancer treatment.

Keywords:
late cardiotoxicity – chemotherapy – radiotherapy – cardio-oncology

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