How to increase the effectiveness of EHK programs for hormones

Česká verzia

Authors: B. Friedecký ^1,2
Authors place of work: Ústav klinické biochemie a diagnostiky, Fakultní nemocnice Hradec Králové ¹; SEKK s. r. o., Pardubice ²
Published in the journal: Klin. Biochem. Metab., 29, 2021, No. 4, p. 216-219

Summary

Objective: Demonstration of low effectivity in programs EQA for hormone in serum and possibilities for its improvement.

Method: Minireview about possibilities of improving reference values for assessment of results, for bias determination and for kind of control materials.

Results: Missing standardization, harmonization and metrological traceability are resolved by using average values from individual methods like EQA reference target for assessment of laboratory results. There are frequently subdivided according to platforms and “generations” of the same producers. It leads to minimalization of validity in quality assessment and paradoxically to falsely high successfulness of labs in EQA. We briefly introduce possibilities of improvement of validity and effectiveness of hormone measurement by different ways. From mathematical recalibration to standardization by means of mass spectrometry methods.

Conclusion: Commutability of control materials and creating the reference systems based on mass spectrometry can resolve poor situation and increase effectiveness of ERQA programs for hormone.

Keywords: EQA, hormones, standardization and harmonization, commutability, effectiveness.

Keywords:

effectiveness – Hormones – EQA – standardization and harmonization – commutability

Zdroje

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Článok vyšiel v časopise

Clinical Biochemistry and Metabolism

2021 Číslo 4

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