Staging of Non‑ Hodgkin’s Lymphoma – Recommendations of the Czech Lymphoma Study Group
Authors:
A. Sýkorová 1; D. Belada 1; L. Smolej 1; R. Pytlík 2; K. Benešová 2; I. Vášová 3; T. Papajík 4; D. Šálek 3; V. Procházka 4
; M. Matuška 5; M. Brejcha 6; K. Kubáčková 7; E. Kabíčková 8; H. Mociková 9; V. Campr 10; M. Trněný 2
Authors place of work:
Oddělení klinické hematologie, II. interní klinika FN HK a LF UK, Hradec Králové
1; I. interní klinika 1. LF UK a VFN, Praha
2; Interní hematoonkologická klinika, FN Brno
3; Hemato-onkologická klinika, FN Olomouc
4; Ústav klinické hematologie, FN Ostrava
5; Onkologické centrum J. G. Mendela, Nový Jičín
6; Radioterapeuticko‑onkologické oddělení, FN Motol, Praha
7; Klinika dětské hematologie a onkologie 2. LF UK a FN Motol, Praha
8; Oddělení klinické hematologie, FN Královské Vinohrady, Praha
9; Ústav patologie a molekulární medicíny 2. LF UK a FN Motol, Praha
10
Published in the journal:
Klin Onkol 2010; 23(3): 146-154
Category:
Reviews
Summary
Backgrounds:
The Ann Arbor system is typically used for the staging of Non‑ Hodgkin‘s lymphomas. This classification was nevertheless originally developed in the 1970s for Hodgkin‘s lymphoma, a disease usually confined to the lymph nodes with less frequent dissemination to extralymphatic organs/ tissues and extremely rare primary extranodal involvement. Non- Hodgkin‘s lymphomas, however, are more often associated with extralymphatic involvement and primary extranodal lymphomas are relatively common (approximately 1/ 3 of cases). Therefore, the value of the Ann Arbor staging system appears to be limited in these cases. An analysis of data from centres participating within the Czech Lymphoma Study Group showed that staging of Non- Hodgkin‘s lymphomas with extranodal involvement is not uniform.
Design:
At the end of 2009, a draft for a Non- Hodgkin‘s lymphomas staging system was put forward for use by the lymphoma register of the Czech Lymphoma Study Group with special regard paid to the involvement of extralymphatic organs/ tissues. This draft was further refined following comments from members of the Czech Lymphoma Study Group committee and the final form was accepted at the meeting of the Czech Lymphoma Study Group committee in January 2010. Results: A consensus was reached at the meeting of the Czech Lymphoma Study Group committee regarding the staging of various combinations of nodal and extranodal involvement. For the purpose of suitable staging and appropriate treatment intensity, extranodal organs were divided into ”major” – liver, lungs, bones, mesothelium (pleura, peritoneum, pericardium) and soft tissues. All other organs were defined as “minor”.
Conclusion:
The Ann Arbor staging system is suitable for the staging of Non‑ Hodgkin‘s lymphomas with lymph node/ lymphatic tissue involvement. As regards the extralymphatic spread of the disease or primary extranodal lymphomas, this classification should rather be adapted to practical needs. The validity of the updated classification system will be assessed in both prospective and retrospective Czech Lymphoma Study Group studies.
Key words:
lymphoma – lymph nodes – staging – classification – recommendations
Zdroje
1. Little RF, Wilson W. Non- Hodgkin‘s lymphoma. In: Rodgers G, Young N (eds). The Bethesda handbook of clinical hematology. 2nd ed. Philadelphia: Lippincott Williams & Wilkins 2009: 196– 216.
2. Adam Z, Krejčí M, Vorlíček J et al. Maligní non‑hodgkinské lymfomy. In: Adam Z, Krejčí M, Vorlíček J et al (eds). Hematologie – přehled maligních hematologických nemocí. 2. vyd. Praha: Grada 2008: 105– 167.
3. Belada D, Trněný M et al. Léčebná doporučení KLS. 4. vyd. Hradec Králové: HK CREDIT s.r.o. 2009: 17– 21.
4. Swerdlov SH, Campo E, Harris NL et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4. vyd. Lyon: IARC 2008.
5. Fabián P, Boudová L. Poznámky ke 4. vydání klasifikace lymfomů WHO. Klin Onkol 2009; 22(3): 121– 22.
6. Shipp MA. Prognostic factors in aggressive non‑Hodgkin’s lymphoma: who has “high‑risk” disease? Blood 1994; 83(5): 1165– 1173.
7. Sehn LH, Berry B, Chhanabhai M et al. The revised International Prognostic Index (R‑ IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B‑ cell lymphoma treated with R‑ CHOP. Blood 2007; 109(5): 1857– 1861.
8. Solal‑ Céligny P, Roy P, Colombat P et al. Follicular lymphoma international prognostic index. Blood 2004; 104(5): 1258– 1265.
9. Federico M, Bellei M, Marcheselli L. Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project. J Clin Oncol 2009; 27(27): 4555– 4562.
10. Hoster E, Dreyling M, Klapper W et al. German Low Grade Lymphoma Study Group (GLSG); European Mantle Cell Lymphoma. A new prognostic index (MIPI) for patients with advanced‑stage mantle cell lymphoma. Blood 2008; 111(2): 558– 565.
11. Gallamini A, Stelitano C, Calvi R et al. Intergruppo Italiano Linfomi. Peripheral T‑ cell lymphoma unspecified (PTCL‑ U): a new prognostic model from a retrospective multicentric clinical study. Blood 2004; 103(7): 2474– 2479.
12. Ferreri AJ, Blay JY, Reni M et al. Prognostic scoring system for primary CNS lymphomas: The International Extranodal Lymphoma Study Group Experience. J Clin Oncol 2003; 21(2): 266– 272.
13. Adam Z, Vorlíček J et al. Vyjádření rozsahu nemoci (klinického stadia) u maligních lymfoproliferativních nemocní a hodnocení léčebné odpovědi. In: Adam Z, Vorlíček J et al (eds). Hematologie II – přehled maligních hematologických nemocí. 1. vyd. Praha: Grada 2001: 245– 250.
14. Gupta RK, Gospodarowicz MK, Lister TA. Clinical evaluation and staging of Hodgkin’s disease. In: Mauch PM, Armitage JO, Diehl V et al (eds). Hodgkin’s disease. 1st ed. Philadelphia: Lippincott Williams & Wilkins 1999: 223– 240.
15. American Joint Committee on Cancer. Lymphoid neoplasms. AJCC Cancer Staging Manual. 6th ed. New York: Springer 2002: 393– 406.
16. Carbone PP, Kaplan HS, Musshoff K et al. Report of the Committee on Hodgkin’s Disease Staging Classification. Cancer Res 1971; 31(11): 1860– 1861.
17. Rosenberg SA. Report of the committee on the staging of Hodgkin’s disease. Cancer Res 1966; 26: 1310.
18. Lister TA, Crowther D, Sutcliffe SB et al. Report of a commitee convened to discuss the evaluation and staging of patients with Hodgkin’s disease: Cotswolds Meeting. J Clin Oncol 1989; 7(11): 1630– 1636.
19. Zucca E. Extranodal lymphoma: a reappraisal. Ann Oncol 2008; 19(4): iv77– iv80.
20. Krol AD, le Cessie S, Snijder S et al. Primary extranodal non‑Hodgkin’s lymphoma (NHL): the impact of alternative definitions tested in the Comprehensive Cancer Centre West population‑based NHL registry. Ann Oncol 2003; 14(1): 131– 139.
21. Rudders RA, Ross ME, DeLellis RA. Primary extranodal lymphoma: response to treatment and factors influencing prognosis. Cancer 1978; 42(2): 406– 416.
22. Peters MV, Bush RS, Brown TC et al. The place of radiotherapy in the control of non‑Hodgkin‘s lymphoma. Br J Cancer Suppl 1975; 2: 386– 401.
23. Musshoff K. Klinische Stadienteilung der Nicht‑- Hodgkin‑Lymphome. Strahlentherapie 1977; 53: 218– 221.
24. Thieblemont C, Mayer A, Dumontet C et al. Primary thyroid lymphoma is a heterogeneous disease. J Clin Endocrinol Metab 2002; 87(1): 105– 111.
25. Toufarová P, Hora M, Boudová L et al. Lymfomy varlat. Urologie pro praxi 2004; 5(3): 125– 126.
26. Connors JM, Klimo P. Is It an E Lesion or Stage IV? An Unsettled Issue in Hodkin’s Disease Staging. J Clin Oncol 1984; 2(12): 1421– 1423.
27. Al‑ Akwaa AM, Siddiqui N, Al‑ Mofleh IA. Primary gastric lymphoma. World J Gastroenterol 2004; 10(1): 5– 11.
28. Rohatiner A, d’Amore F, Coiffier B et al. Report on a workshop convened to discuss the pathological and staging classifications of gastrointestinal tract lymphoma. Ann Oncol 1994; 5(5): 397– 400.
29. Golling P, Cozzio A, Dummer R et al. Primary cutaneous B‑ cell lymphomas – clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO‑ EORTC classification and the ISCL/ EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome. Leuk Lymphoma 2008; 49(6): 1094– 1103.
30. Kim YH, Willemze R, Pimpinelli N et al. ISCL and the EORTC. TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC). Blood 2007; 110(2): 479– 484.
31. Olsen E, Vonderheid E, Pimpinelli N et al. ISCL/ EORTC. Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the classification of mycosis fungoides and European Organization of Research and Treatment of Cancer (EORTC). Blood 2007; 110(6): 1713– 1722.
32. Cheson BD, Pfistner B, Juweid ME et al. International Harmonization Project on Lymphoma. Revised response criteria for malignant lymphoma. J Clin Oncol 2007; 25(5): 579– 586.
33. Abrey LE, Batchelor TT, Ferreri AJ et al. International Primary CNS Lymphoma Collaborative Group. Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma. J Clin Oncol 2005; 23(22): 5034– 5043.
34. Krol AD, Le Cessie S, Snijder S et al. Waldeyer’s ring lymphomas: a clinical study from the Comprehensive Cancer Center West population based NHL registry. Leuk Lymphoma 2001; 42(5):1005– 1013.
35. Lyons JA, Myles J, Pohlman B et al. Treatment of prognosis of primary breast lymphoma: a review of 13 cases. Am J Clin Oncol 2000; 23(4): 334– 336.
36. Stein ME, Kuten A, Gez E et al. Primary lymphoma of bone – a retrospective study. Experience at the Northern Israel Oncology center (1979– 2000). Oncology 2003; 64(4): 322– 327.
37. Economopoulos T, Papageorgiou S, Rontogianni D et al. Hellenic Cooperative Oncology Group. Multifocal extranodal non‑Hodgkin Lymphoma: A clinicopathologic study of 37 cases in Greece, a Hellenic Cooperative Oncology Group Study. Oncologist 2005; 10(9): 734– 738.
38. Zinzani PL, Martelli M, Poletti V et al. Practice guidelines for the management of extranodal non‑Hodgkin’s lymphomas of adult non‑immunodeficient patients. Part I: primary lung and mediastinal lymphomas. A project of the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation. Haematologica 2008; 93(9): 1364– 1371.
39. Connors JM. Problems in lymphoma management: special sites of presentation. Oncology 1998; 12(2): 185– 195.
40. van der Sanden GA, Schouten LJ, van Dijck JA et al. Primary central nervous system lymphomas: incidence and survival in the Southern and Eastern Netherlands. Cancer 2002; 94(5): 1548–1556.
41. DeAngelis LM. Current management of primary central nervous system lymphoma. Oncology 1995; 9(1): 63–78.
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