Acute Myeloblastic Leukaemia with Alternationsof MLL Proto-Oncogene Protein (11q23/ MLL+ AML)

Česká verzia

Authors: Z. Mikulášová ¹; D. Ilenčíková ^1,2; T. Slamka ¹; D. Ďurovčíková ²
Authors place of work: Oddelenie onkologickej genetiky, Národný onkologický ústav, Bratislava, Slovenská republika ¹; Katedra lekárskej genetiky SZU‑ FZŠŠ, Bratislava, Slovenská republika ²
Published in the journal: Klin Onkol 2010; 23(6): 401-407
Category: Reviews

Summary

One of the most common chromosomal breakpoint regions in acute myeloid leukaemia is the chromosome band 11q23. The analysis of this region led to the discovery of the extremely promiscuous MLL gene, in which more than 60 MLL translocation partner genes have been described. Among the most frequent are t(9;11)(p21– 22;q23)/ MLL‑ AF9, t(10;11)(p13;q23)/ MLL‑ AF10, t(11;19)(q23;p13)/ MLL‑ ELL, ENL and t(6;11)(q27;q23)/ MLL‑ AF6. The presented work provides an overview of the molecular mechanisms by means of which MLL proto‑ oncogene can be converted into oncogene. Genetic alternations of the MLL Proto-Oncogene Protein besides translocation are also represented by complex chromosomal rearrangements, deletions, insertions, partial tandem duplications, amplifications and gains. These genetic alterations are described in the work from the diagnostic and prognostic point of view. Abnormalities of the MLL Proto-Oncogene Protein are usually connected with bad prognosis. For that reason, in oncological practice, particular attention is paid to introducing new genetic methods for their identification. The above work gives well arranged information about different types of genetic tests and their outcomes, which can help oncologists in predicting the prognosis, in minimal residual disease monitoring and in modifying oncological patient treatment.

Key words:
acute myeloid leukaemia – MLL Proto-Oncogene Protein – chromosomal translocations

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