Partial Regression of CNS Lesions of Erdheim-Chester Disease after Treatment with 2-chlorodeoxadenosine and Their Full Remission Following Treatment with Lenalidomide
Authors:
Z. Adam 1; A. Šprláková 2; Z. Řehák 3; R. Koukalová 3; P. Szturz 1; M. Krejčí 1; L. Pour 1; L. Zahradová 1; L. Červinek 1; L. Křen 4; M. Moulis 1; M. Hermanová 5; M. Mechl 2; J. Prášek 6; R. Hájek 1; Z. Král 1; J. Mayer 1
Authors place of work:
Interní hematoonkologická klinika, LF MU a FN Brno
1; Radiologická klinika, LF MU a FN Brno
2; Oddělení PET CT, Masarykův onkologický ústav, Brno
3; Ústav patologie, LF MU a FN Brno
4; Ústav patologické anatomie, LF MU a FN Brno
5; Klinika nukleární medicíny, Brno
6
Published in the journal:
Klin Onkol 2011; 24(5): 367-381
Category:
Case Reports
Summary
Introduction:
Erdheim-Chester disease is a very rare syndrome affecting adult population. It typically causes hyperostosis of long bones, retroperitoneal fibrosis and widening of the aortic wall. Patients frequently suffer from disease-associated fevers and pain in the lower limbs. No guidelines are available for the treatment of this rare ailment. Therefore, we describe our experience with lenalidomide in a patient with poor treatment response to 2-chlorodeoxyadenosine.
Case:
Diabetes insipidus and neurological problems developing over 4 years were the first signs of the disease. The disease was diagnosed from histology of the bone marrow extracted from the ilium. At diagnosis, the patient had multiple infiltrates in the brain, widened wall of the thoracic and abdominal aorta, fibrotic changes to retroperitoneum and typical hyperostosis of the long bones of lower limbs with high accumulation of technetium pyrophosphate as well as fluorodeoxyglucose. First line treatment involved 2-chlorodeoxyadenosine 5 mg/m2 s.c. for 5 consecutive days every 28 days. There was no clear treatment response identifiable on the MR scan of the brain following the third cycle and thus 4th–6th2 + cyclophosphamide 150 mg/m2 + dexamethasone 24 mg day 1–5 every 28 days. After the 6th cycle, MR showed partial regression of the brain lesions. PET-CT showed an increased accumulation of fluorodeoxyglucose in bone lesions. Second line treatment involved lenalidomide 25 mg/day days 1–21 every 28 days. Lenalidomide tolerance was excellent; the number of neutrophils and thrombocytes was within the physiological range throughout the treatment period. Follow-up MR showed complete remission of the brain lesions, while follow-up PET-CT showed further increase in fluorodeoxyglucose accumulation in the bones of lower limbs.
Conclusion:
Treatment with 2-chlorodeoxyadenosine-based regimen provided partial remission of Erdheim-Chester disease lesions in the brain, while treatment with lenalidomide resulted in complete remission of these lesions. Fluorodeoxyglucose continues to accumulate in the long bones of lower limbs. We are unable to elucidate the reasons for complete remission of the disease in the brain as per the MR and its progression in the long bones according to PET-CT. Further testing of lenalidomide in the treatment of this disease is required to support further use of this perspective treatment option.
Key words:
Erdheim-Chester disease – juvenile xanthogranuloma – osteosclerosis – skeletal scinigraphy – PET-CT – lenalidomide – 2-chlorodeoxyadenosine – cladribin – retroperitoneal fibrosis
This study was supported by the research programme of the Ministy of Health of the CR FUNDIN MZ0MOU2005 and prepeared as part of the Internal Grant Agency of the Czech Republic grants NT 12215-4, the Ministry of Education, Youth and Sports of the CR grants MSM0021622434, LC06027 and the Ministry of Health of the Czech Republic’s Internal Grant Agency grants IGA MZd NT11154, NT12130, NT12215 and NS10408.
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
Submitted:
14. 3. 2011
Accepted:
16. 5. 2011
Zdroje
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Štítky
Paediatric clinical oncology Surgery Clinical oncologyČlánok vyšiel v časopise
Clinical Oncology
2011 Číslo 5
- Spasmolytic Effect of Metamizole
- Metamizole at a Glance and in Practice – Effective Non-Opioid Analgesic for All Ages
- Metamizole in perioperative treatment in children under 14 years – results of a questionnaire survey from practice
- Current Insights into the Antispasmodic and Analgesic Effects of Metamizole on the Gastrointestinal Tract
- Obstacle Called Vasospasm: Which Solution Is Most Effective in Microsurgery and How to Pharmacologically Assist It?
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