Preimplantation Genetic Diagnosis (PGD) of Hereditary Cancer Syndromes

Česká verzia

Authors: L. Raszyková; V. Hořínová; P. Texl
Authors place of work: Laboratoř lékařské genetiky, Sanatorium Helios, Brno
Published in the journal: Klin Onkol 2012; 25(Supplementum): 84-86

Summary

Advances in molecular biology techniques made possible genotype analysis from one or several cells. This can be used in preimplantation genetic diagnosis (PGD) not only of chromosomal aneuploidy but also of single gene diseases as well as hereditary cancer syndromes. PGD can be a benefit for those cases when the risk of transfer of pathological alteration from parent to offspring is unwelcome. We submit three cases of PGD with the results.

Key words:
preimplantation genetic diagnosis – single gene disease – hereditary cancer syndromes – in vitro fertilization

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
27. 4. 2012

Accepted:
25. 6. 2012

Zdroje

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