Surgical Prevention of Breast Carcinoma in Patients with Hereditary Risk

Česká verzia

Authors: L. Dražan ¹; J. Veselý ¹; P. Hýža ¹; T. Kubek ¹; L. Foretová ²; O. Coufal ²
Authors place of work: Klinika plastické a estetické chirurgie, Fakultní nemocnice u sv. Anny v Brně ¹; Masarykův onkologický ústav, Brno ²
Published in the journal: Klin Onkol 2012; 25(Supplementum): 78-83

Summary

Background:
Women with BRCA1 gene mutation have 85% risk of breast cancer; the risk for BRCA2 carriers is 45%. The aim of the study was to verify if prophylactic mastectomy with immediate breast reconstruction can prevent breast cancer in BRCA positive patients.

Material:
There were 100 BRCA positive women in which prophylactic mastectomy with immediate reconstruction, 75 dieps, 25 with implants, performed in period 2000–2011. Group A was composed of healthy, non-affected 41 patients, group B of 59 patients in remission after breast cancer treatment. These groups were compared to group C that consisted of 219 healthy carriers of BRCA1/2, non-operated, from registry of genetic department of the Masaryk Memorial Cancer in Brno, from 2000–2011.

Method:
Follow-up for oncology status was done in September 2011 for all 3 groups.

Results:
Average follow-up of 21 months revealed that in group A there was no breast cancer, in group B 4 patients died and 2 had treatment for metastases. In group C, there were 16 new cases of breast cancer.

Conclusion:
Bilateral prophylactic mastectomy with immediate reconstruction can be an effective way in breast cancer prevention in healthy carriers of BRCA1/2 mutation. In BRCA positive patients treated for breast cancer, the effect of prophylactic mastectomy is unclear. Their survival is more influenced by their previous disease than by a new tumor in the breast.

Key words:
prophylactic mastectomy – BRCA – immediate breast reconstruction

The study was supported by:
grant of Internal Grant agency of the Czech Ministry of health No. Ns10401-3. Genetical testing was supported by the EU Operational Program OP VaVpI – RECaMO and by development project of the Government of the Czech Republic under contract No.CZ.1.05/2.1.00/03.0101.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
18. 4. 2012

Accepted:
21. 5. 2012

Zdroje

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