Smoking and Breast Cancer

Česká verzia

Authors: D. Hrubá
Authors place of work: Ústav preventivního lékařství LF MU, Brno
Published in the journal: Klin Onkol 2013; 26(6): 389-393
Category: Review

Summary

Background:
Investigation of the relationship between smoking and breast cancer risk did not show a consensus in results – some studies described smoking as a risk factor, while others found its effects protective.

Purpose:
The newest studies explain these differences by the genetic polymorphism. Cigarette smoke contains at least 20 chemical carcinogens, which are deposited and metabolically activated in the breast and surrounding adipose tissues. The substances are further detected in the nipple discharge or as smoking‑ specific DNA adducts in breast tissue. Several studies postulate significantly higher risk of breast cancer among women who started smoking at an early age and/ or before their first delivery. Some studies from Japan, China, California have shown that long‑term exposure to passive smoking could significantly increase the risk of breast cancer in never smokers, while other scientist reject the evidence of this association as inconsistent. A possible protective effect of smoking on the incidence of breast cancer is explained by antiestrogenic activity of smoking, namely nicotine.

Conclusion:
Smoking may play a role in the breast cancer incidence. Due to a wide spectrum of harmful effects of smoking, and with regards to the worse prognosis of breast cancer among smoking patients, the common recommendations for cancer prevention are similarly plausible in case of breast cancer – no‑ smoking, no alcohol, fruit and vegetable consumption, physical activity and body weightcontrol.

Key words:
smoking – breast neoplasms – epidemiologic studies

The author declare she has no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
17. 6. 2013

Accepted:
27. 6. 2013

Zdroje

1. Gaudet MM, Gapstur SM, Sun J et al. Active smoking and breast cancer risk: original cohort data and meta‑analysis. J Natl Cancer Inst 2013; 105(8): 515– 525.

2. Hecht SS. Tobacco smoke carcinogens and breast cancer. Environ Mol Mutagen 2002; 39(2– 3): 119– 126.

3. International Agency for Research on Cancer. A review of human carcinogens: personal habits and indoor combustion. Lyon: IARC 2012: 100E.

4. California Environmental Protection Agency. Health effects assessment for ETS: Final. Sacramento, CA: California EPA 2005.

5. Collishaw NF, Boyd NF, Cantor KP et al. Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk. Toronto: Ontario Tobacco research Unit 2009.

6. MacNicoll AD, Easty GC, Neville AM et al. Metabolism and activation of carcinogenic polycyclic aromatic hydrocarbons in human mammary cells. Biochem Biophys Res Commun 1980; 93(4): 1599– 1606.

7. Petrakis NL, Maack CA, Lee RF et al. Mutagenic activity in nipple‑ aspirates of human breast fluid. Cancer Res 1980; 40(1): 188– 189.

8. Li D, Zhang W, Sabin AA et al. DNA adducts in normal tissue adjacent in breast cancer: a review. Cancer Detect Prev 1999; 23(6): 454– 462.

9. Rubdle A, Tang D, Hibshoosh H et al. The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer. Carcinogenesis 2000; 21(7): 1281– 1289.

10. Terry PD, Rohan TE. Cigarette smoking and the risk of breast cancer in women: a review of the literature. Cancer Epidemiol Biomarkers Prev 2002; 11(10 Pt 1): 953– 971.

11. Deitz AC, Zheng W, Leff MA et al. N‑ acetyltransferase 2 genetic polymorpfism, well‑done meat intake, and breast cancer among postmenopausal women. Cancer Epidemiol Biomarkers Prev 2000; 9(9): 905– 910.

12. Reynolds P, Hurley S, Goldberg DE et al. Active smoking, household passive smoking, and breast cancer: evidence from the California Teachers Study. J Natl Cancer Inst 2004; 96(1): 29– 37.

13. Conlon MS, Johnson KC, Bewick MA et al. Smoking (active and passive), N‑ acetyltransferase 2, and risk of breast cancer. Cancer Epidemiol 2010; 34(2): 142– 149.

14. US Department of Health and Human Services: The Health consequences of Smoking: A Report of the Surgeon General. Atlanta, GA. US DHHS, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office of Smoking and Health, 2004.

15. Baron JA, La Vecchia C, Levi F. The antiestrogenic effect of cigarette smoking in women. Ann J Obstet Gynecol 1990; 162(2): 502– 514.

16. Tankó LB, Christiansen C. An update on the antiestrogenic effect of smoking: a literature review with implications for researchers and practicioners. Menopause 2004; 11(1): 104– 109.

17. Mlynareikova A, Pickova M, Sesukova S. Ovarian intrafollicular processes as a target for cigarette smoke components and selected environmental reproductive disruptors. Endocr Regul 2005; 39(1): 21– 32.

18. Wong PK, Christie JJ, Wark JD. The effects of smoking on bone health. Clin Sci (Lond) 2007; 113(5): 233– 241.

19. MacMahon B, Trichopoulos D, Cole P et al. Cigarette smoking and urinary estrogens. N Engl J Med 1982; 307(17): 1062– 1065.

20. Butler LM, Gold EB, Conroy SM et al. Active, but not passive cigarette smoking was inversely associated with mammographic density. Cancer Causes Control 2010; 21(2): 301– 311.

21. Roubidoux MA, Kaur JS, Griffith KA et al. Relationship of mammographic parenchymal patterns to breast cancer risk factors and smoking in Alaska Native women. Cancer Epidemiol Biomarkers Prev 2003; 12(10): 1081– 1086.

22. Boyd NF, Martin LJ, Sun L et al. Body size, mammographic density, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2006; 15(11): 2086– 2092.

23. Schneider J, Huh MM, Bradlow HL et al. Antiestrogen action of 2– hydroxyestrone on MCF‑ 7 human breast cancer cells. J Biol Chem 1984; 259(8): 4840– 4845.

24. Martin LJ, Boyd NF. Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence. Breast Cancer Res 2008; 10(1): 201.

25. Key TJ, Appleby PN, Reeves GK et al. Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies. Br J Cancer 2011; 105(5): 709– 722.

26. Nagata C, Mizoue T, Tanaka K et al. Tobacco smoking and breast cancer risk: an evaluation based on a systematic review of epidemiological evidence from the Japanese population. Jap J Clin Oncol 2006; 36(6): 387– 394.

27. Himajima N, Hirose K, Tajima K et al. Alcohol, tobacco and breast cancer – collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer 2002; 87(11): 1234– 1245.

28. Chen Z, Shao J, Gao X et al. Effect of passive smoking and female breast cancer in China: A meta‑analysis. Asia Pac J Public Health 2013. In press.

29. Seitz HK, Pelucchi C, Bagnardi V et al. Epidemiology and pathophysiology of alcohol and breast cancer: update 2012. Alcohol 2012; 47(3): 204– 212.

30. Chen WY, Rosner B, Hankinson SE et al. Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. JAMA 2011; 306(17): 1884– 1890.

31. Cui Y, Miller AB, Rohan TE. Cigarette smoking and breast cancer risk: update of a prospective cohort study. Breast Cancer Res Treat 2006; 100(3): 293– 299.

32. Luo J, Margolis KL, Wactawski‑ Wende J et al. Associations of active and passive smoking with risk of breast cancer among postmenopausal women: a prospective cohort study. BMJ 2011; 342: d1016.

33. Xue F, Willett WC, Rosner BA et al. Cigarette smoking and the incidence of breast cancer. Arch Intern Med 2011; 171(2): 125– 133.

34. Murin S, Inciardi J. Cigarette smoking and the risk of pulmonary metastasis from breast cancer. Chest 2001; 119: 1635– 1640.

35. Fentiman IS, Allen DS, Hamed H. Smoking and prognosis in women with breast cancer. Int J Clin Pract 2005; 59(9): 1051– 1054.

36. England A, Andersen A, Haldorsen T et al. Smoking habits and risk of cancers other than lung cancer: 28 years’ follow‑up of 26,000 Norwegian men and women. Cancer Causes Control 1996; 7(5): 497– 506.

37. Nordlund LA, Carstensen JM, Pershagen G. Cancer incidence in female smokers: a 26‑year follow‑up. Int J Cancer 1997; 73(5): 625– 628.

38. Al‑ Delaimy WK, Cho E, Chen WY et al. A prospective study of smoking and risk of breast cancer in young adult women. Cancer Epidemiol Biomarkers Prev 2004; 13(3): 398– 404.

39. Olson J. Young women who smoke higher risk of breast cancer. Mayo Clinic Proceedings Study emphasizes need for smoking prevention messages 2005; 80(11): 1423– 1448. Available from: http:/ / www.mayoclinic.org/ news.

40. Dítětová I. Známe skutečně všechny rizikové faktory karcinomu prsu? Prakt Lék 2000; 80(2): 84– 87.

41. Rameš J, Valenta Z, Bencko V. Rizikové faktory prostředí a životního stylu u karcinomu prsu žen: dotazníkové šetření. Hygiena 2008; 53(4): 127– 134.

42. Russo J, Moral R, Balogh GA et al. The protective role of pregnancy in breast cancer. Breast Cancer Res 2005; 7(3): 131– 142.

43. DeRoo LA, Cummings P, Mueller BA. Smoking before the first pregnancy and the risk of breast cancer: a meta‑analysis. Am J Epidemiol 2011; 174(4): 390– 402.

44. Gram IT, Braaten T, Terry PD et al. Breast cancer risk among women who start smoking as teenagers. Cancer Epidemiol Biomarkers Prev 2005; 14(1): 61– 66.

45. Hanaoka T, Yamamoto S, Sobue T et al. Active and passive smoking and breast cancer risk in middle‑ aged Japanese women. Int J Cancer 2005; 114(2): 317– 322.

46. Reynolds P, Goldberg DE, Hurley S et al. Passive smoking and risk of breast cancer in the California Teachers Study. Cancer Epidemiol Biomarkers Prev 2009; 18(12): 3389– 3398.

47. Millionwomenstudy.org [homepage on the Internet]. UK/ US: Million Women Study: Report questions passive smoking‑ breast cancer link. Available from: http:/ / www.millionwomenstudy.org/ .

48. Pirie K, Beral V, Peto R et al. Passive smoking and breast cancer in never smokers: prospective study and meta‑analysis. Int J Epidemiol 2008; 37(5): 1069– 1079.

49. Rollison DE, Brownson RC, Hathcock HL et al. Case‑ control study of tobacco smoke exposure and breast cancer risk in Delaware. BMC Cancer 2008; 8: 157.

50. Terry PD, Thun MJ, Rohan TE. Does tobacco smoke cause breast cancer? Women Health (Lond Engl) 2011; 7(4): 405– 408.

51. Shen J, Terry MB, Gammon MD et al. MGTM genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer risk. Carcinogenesis 2005; 26(12): 2131– 2137.

52. Tang LY, Chen LJ, Qi ML et al. Effects of passive smoking on breast cancer risk in pre/ post‑menopausal women as modified by polymorphisms of PARP1 and ESR1. Gene 2013; 524(2): 84– 89.

53. Slattery ML, Curtin K, Giuliano AR et al. Active and passive smoking, IL6, ESR1, and breast cancer risk. Breast Cancer Res Treat 2008; 109(1): 101– 111.

54. Mechanic LF, Millikan RC, Player J et al. Polymorphisms in nucleotid excision repair genes, smoking and breast cancer in African Americans and whites: a population‑based case‑ control study. Carcinogenesis 2006; 27(7): 1377– 1385.

55. McKenzie F, Ellison‑ Loschmann L, Jeffreys M et al. Cigarette smoking and risk of breast cancer in a New Zealand Multi‑Ethnic Case‑ Control Study. PLoS One 2013; 8(4): e63132.

56. Johnson KC, Miller AB, Collishaw NE et al. Active smoking and secondhand smoke increase breast cancer risk: the report of the Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk. Tob Control 2011; 20(1): e2.

57. Secretan B, Straif K, Baan R et al. A review of human carcinogens – part E: tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol 2009; 10(11): 1033– 1034.

58. Ebbs S (ed.). Smoking and breast cancer – Editorial [monograph on the Internet]. Available from: http:/ / www.blackwell‑synergy.com/ doi/ full/ 10.1111/ j.1742– 1241.2005.00580.x.