Effect of Vitamin D Receptor Polymorphisms on the Development and Progression of Malignant Melanoma

Česká verzia

Authors: I. Špaková ¹; M. Bilecová‑ rabajdová ¹; M. Zábavníková ²; P. Urban ¹; M. Mareková ¹
Authors place of work: Ústav lekárskej a klinickej biochémie LF UPJŠ a LABMED, a. s., Košice ¹; Klinika plastickej, rekonštrukčnej a estetickej chirurgie LF UPJŠ a UN LP Košice ²
Published in the journal: Klin Onkol 2014; 27(3): 173-177
Category: Review

Summary

Background:
Malignant melanoma is one of the most aggressive cutaneous tumors in men and women. The risk of developing a malignant melanoma depends on several external factors along with deregulation of mutual interaction of genotype and phenotype. Nowadays, growing attention is focused on the study of the interactions of the active form of vitamin D₃ with its receptor and inhibitory effect of vitamin D₃ receptor polymorphisms on multiple signaling pathways involved in proliferative and metastatic processes.

Objectives:
This review article addresses the relationship between factors involved in the development of malignant melanoma through Hedgehog signaling pathway (HH). It summarizes current knowledge of malignant melanoma in regard to the role of the active form of vitamin D₃ binding to vitamin D₃ receptor (VDR), as well as it describes the influence of polymorphisms of VDR on the inhibition of HH. Understanding of these mechanisms and critical assessment of available data is beneficial to both primary and secondary prevention of malignant melanoma particularly by means of chemo‑ preventive substances.

Key words:
vitamin D₃ – Hedgehog signalisation – melanoma – calcitriol – skin cancer

This work was supported by by the grant DIAGONKO ITMS:
26220220153.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
21. 12. 2013

Accepted:
25. 2. 2014

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