Positron Emission Tomography Combined with Computed Tomography for Diagnosis of Synchronous Tumors

Pozitronová emisní tomografie kombinovaná s počítačovou tomografií pro diagnózu synchronních nádorů

Východiska:
Hybridní metoda 18F-FDG PET/ CT byla prokázána jako metoda volby v onkologii pro diagnostiku, staging, restaging nádorových onemocnění a vyhodnocení terapeutického účinku. Cílem této studie bylo zjistit hodnotu 18F-FDG PET/ CT pro detekci synchronních nádorů a tedy i vliv na léčbu pacienta.

Materiál a metody:
Vyšetření byla provedena na Discovery, GE Healthcare PET/ CT s použitím standardního protokolu. Mezi pacienty, vyšetřenými 18F‑ FDG PET/ CT za jeden rok (n = 1 408), byly neočekávané synchronní nádory detekovány v 11 případech (0,8 %).

Výsledky:
Jako sekundární malignity jsme detekovali pět plicních karcinomů, čtyři spinocelulární karcinomy hlavy a krku (head and neck squamous cell carcinomas – HNSCC), jeden ovariální karcinom a jeden nádor sigma. Ověření histologií bylo provedeno v pěti případech (všechny HNSCC a jeden karcinom sigma). U jednoho pacienta s karcinomem ovaria byla histologie získána po operaci. Ve zbytku pacientů nebyla provedena žádná kontrola, kvůli odmítnutí pacienta a pokročilému stadiu onemocnění, které vyžadovalo náročnou systémovou chemoterapii. Čtyři pacienti (tři s HNSCC a jedna se sekundární malignitou vaječníků) měli příznivý výsledek během devíti měsíců sledování.

Závěr:
Hybridní metoda PET/ CT, která kombinuje metabolické a morfologické nálezy, může pomoci detekovat synchronní malignity byť v malém procentu případů, ale s pozitivním vlivem na léčbu části těchto pacientů.

Klíčová slova:
PET/CT – synchronní tumory – multidisciplinární péče

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Obdrženo:
6. 4. 2014

Přijato:
16. 4. 2014

Authors: M. Garcheva ¹; D. Zlatareva ²; L. Gocheva ¹
Authors place of work: Clinical Center of Nuclear Medicine, Radiotherapy, and Medical Oncology Medical University, Sofia, Bulgaria ¹; Department of Diagnostic Imaging, Medical University, Sofia, Bulgaria ²
Published in the journal: Klin Onkol 2014; 27(4): 283-286
Category: Case Report

Summary

Background:
The hybrid method 18F-FDG PET/ CT has been proven as a method of choice in oncology for diagnostics, staging, restaging of the tumor and evaluation of the therapeutic effect. The aim of the study was to determine the value of 18F-FDG PET/ CT for detection of synchronous tumors and consequently the influence on the patients’ management.

Material and Methods:
The examinations were performed on Discovery, GE Healthcare PET/ CT using standard protocol. Among the patients, examined by 18F‑ FDG PET/ CT for one year (n = 1 408), unsuspected synchronous tumors were detected in 11 cases (0.8%).

Results:
Five pulmonary carcinomas, four head and neck squamous cell carcinomas (HNSCC), one ovarian carcinoma and one tumor of the sigma were detected as second malignancies. The histology verification was done in five cases (all HNSCC and one sigma carcinoma). In one patient with ovarian carcinoma, histology was obtained after surgery. In the rest of patients, no verification was undertaken because of the patients’ refusal and the advanced stage of the diseases, demanding systemic chemotherapy. Four patients (three with HNSCC and one with ovarian secondary malignancy) had favorable outcome during the nine‑ month follow‑up.

Conclusion:
The hybrid method PET/ CT, combining the metabolic and morphologic findings, can help detection of synchronous malignancies in a small percentage of cases, but with a positive influence on management of considerable part of such patients.

Key words:
PET/CT – synchronous tumors – multidisciplinary cancer care

Introduction

18F- FDG PET/ CT is widely used in oncology not only for determination of diagnosis, for staging and therapy planning but also for evaluation of therapeutic effect. Some of examined patients are known to have secondary malignancy. The aim of this study was to evaluate the rate of unexpected synchronous tumors, detected by PET/ CT as incidental finding and to determine if it influences patients’ management.

Material and methods

The examinations were performed on 16- slice PET/ CT scanner Discovery GE Healthcare using F- 18 FDG and standardized protocol of examination. The evaluation was generally done by visual assessment and semi quantitatively. PET/ CT was interpreted by a specialist in nuclear medicine for PET examination and a radiologist for whole‑ body CT examination.

Results

Altogether, 1,408 patients were examined in one year; unsuspected synchronous tumors were detected in 11 of them (0.8%) (three men and eight women, mean age 57.9 ± 6 years). We found the following secondary malignancy: lung tumors in five patients, head and neck tumors in four patients, ovarian carcinoma in one patient and colorectal tumor in one patient. A follow‑up for nine months was done. From patients with lung carcinoma (primary or synchronous disease; n = 6), four of patients had advanced disease at the time of examination, and two had progression during the follow‑up. From patients with head and neck squamous cell carcinoma (HNSCC) as a synchronous tumor (n = 4), three had complete response after therapy which was planned for both tumors. The patient with ovarian carcinoma synchronously detected with breast cancer had stable disease after change of management. In four patients, the management was changed in order to include surgery and radiotherapy, or surgery and chemotherapy for the synchronous tumor. The follow‑up examinations demonstrated favorable outcome.

Case 1

A 65‑year old male after extirpation of small‑cell variant of neuroendocrine tumor (NET) in anorectal region

PET/ CT was indicated for restaging. Coronal maximum‑ intensity‑ projection (MIP) PET image (Fig. 1A), sagittal and axial PET/ CT image demonstrate asymmetry of the larynx with increased FDG uptake in the left part SUV max 11.5 (Fig. 1B– D). Increased metabolism is present in enlarged neck, paratracheal, precarinal and subcarinal, aortopulmonal and both hilar lymphonodes. There was a suspicion of another primary tumor of the larynx with dissemination into the neck, mediastinal and hilar lymphonodes. The patient had histologic verification and both radiotherapy of the laryngeal carcinoma and chemotherapy were applied. Eight months later on the follow‑up PET/ CT, there was a complete response to the applied treatment (Fig. 1E– G).

**Fig. 1A. Coronal maximum-intensity-projection (MIP) PET.**

**Fig. 1B–D. Sagittal and axial PET/CT image.**

**Fig. 1E–G. Eight months later on the follow-up PET/CT.**

Case 2

A 66‑year old male with diagnosed cancer of the left lung after left upper lobectomy, recurrence, chemotherapy and treatment with cyber knife (Fig. 2A–E)

**Fig. 2B. Coronal CT image (lung window).**

PET/ CT helps to differentiate postoperative and radiation fibrosis of the left lung from recurrence what is impossible only on CT. Both adrenals appear normal. There is a liver metastasis and enlarged abdominal retroperitoneal and perigastral lymphonodes with increase FDG uptake. On PET/ CT there is a suspicion of another primary tumor with origin of sigmoid colon which was histologically proven (Fig. 2E).

Discussion

Synchronous malignancies could change the patients’ prognosis. According to publications, synchronous tumors in the „aerodigestive area“ are a well‑known phenomenon that has been explained by the concept of „field cancerization“ [1– 6]. The mucous epithelium of the head and neck, lung, and esophagus is exposed to common carcinogenic agents, such as tobacco and alcohol which promote carcinogenesis [7]. Published data about incidence of synchronous cancers concern mainly patients with esophageal cancer [8,9]. Frequently reported sites of synchronous tumors are head and neck, stomach, lung, and urinary bladder [10,11]. FDG/ PET is reported to be good in detection of occult head and neck squamous cell carcinomas (HNSCC) and lung carcinomas, as were the most of synchronous malignancies detected in this study. In this study, they were frequently related to colorectal tumors (in 4/ 11 cases, 36%). The co‑ morbidity of lung carcinoma and breast carcinoma was also frequent, without relationship to the site of performed radiotherapy.

According to literature, FDG‑ PET is more successful than conventional evaluation [12– 19] for HNSCC. The sensitivity of PET was reported to be 10– 60% [20], and high even for patients with negative physical and MRI examination [21]. In the early‑stage of the disease, 80% of the patients have good prognosis after definitive locoregional treatment. For patients with advanced stage, the identification of the tumor site is important to guide the resection and to limit the extent of radiotherapy. This improves the locoregional control and overall survival [22,23]. In our patients with incidentally detected HNSCC, the follow‑up demonstrated good results from the management of the synchronous tumor. For the ovarian cancer detected incidentally, the follow‑up of nine months demonstrated also neither relapse, nor dissemination of the disease.

Conclusion

Knowing the pattern of dissemination of tumors, some of the detected lesions and pathological findings can be addressed to other primary tumor, what can significantly influence management of the patient. The rate of the detected synchronous malignancies is not high, but the careful interpretation, observation and histological confirmation can influence the patients’ management and prognosis.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Assoc. Prof. Dr. Marina Garcheva

Department of Nuclear Medicine

Medical University Sofia

Zdrave Street 2

1431 Sofia

Bulgaria

e-mail: marina.garcheva@gmail.com

Submitted: 6. 4. 2014

Accepted: 16. 4. 2014

Zdroje

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