Modern Nanomedicine in Treatment of Lung Carcinomas

Česká verzia

Authors: Z. Heger ¹; T. Eckschlager ²; M. Stiborová ³; V. Adam ¹; O. Zítka ¹; R. Kizek ¹
Authors place of work: Laboratoř metalomiky a nanotechnologií, Ústav chemie a biochemie, Mendelova univerzita v Brně ¹; Klinika dětské hematologie a onkologie 2. LF UK a FN v Motole, Praha3 Katedra biochemie, Přírodovědecká fakulta, UK v Praze ²
Published in the journal: Klin Onkol 2015; 28(4): 245-250
Category: Review
doi: https://doi.org/10.14735/amko2015245

Summary

Backgrounds:
Despite the fast development of new effective cytostatics and targeted therapy, the treatment efficiency of lung cancer is still insufficient. The systemic administration of drugs results in a decrease in drug concentrations in tumor site, particularly due to specific extracellular environment in lungs. Nanotransporters could serve as a platform, protecting a drug against these undesired effects, which may enhance its therapeutic index and reduce side effects of a drug. Moreover, nanotechnologies possess the potential to improve the diagnostics of lung cancer, and thus increase a survival rate of oncologic patients.

Aim:
The presented study is aimed to demonstrate the possibilities provided by nanotechnologies in the field of treatment and diagnostic of lung cancers and discuss the obstacles, which complicate a translation into clinical practice.

Key words:
targeted delivery – liposomes – nanoparticles – non‑small cell lung cancer – small cell lung cancer

The study was supported by League Against Cancer Prague (project 18257/2014-981) and by the Czech Ministry of Health – RVO, FN v Motole 00064203.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
21. 3. 2015

Accepted:
11. 5. 2015

Zdroje

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