Carcinoid of the Appendix Goblet Cells Metastasize to the Orbit – a Clinical Case Report and Review of the Literature
Authors:
V. M. Matějka 1; P. Mukenšnabl 2; R. Tupý 3; O. Fiala 1; J. Fínek 1
Authors place of work:
Onkologická a radioterapeutická klinika LF UK a FN Plzeň
1; Šiklův ústav patologie, LF UK a FN Plzeň
2; Klinika zobrazovacích metod LF UK a FN Plz
3
Published in the journal:
Klin Onkol 2016; 29(3): 220-223
Category:
Case Reports
doi:
https://doi.org/10.14735/amko2016220
Summary
Goblet cell carcinoid (GCC) of the appendix is extremely rare, representing approximately 5% of all primary appendiceal neoplasms. Histologically there are three groups of GCC: group A (typical GCC), adenocarcinoma ex GCC signet ring cell type (group B), and adenocarcinoma ex GCC poorly differentiated carcinoma type (group C), which is the most aggressive. GCC metastasizes in 15–60% of cases, mainly to the ovaries, pelvis, abdominal cavity, ribs, vertebrae, and lymph nodes. Hematogenous metastasis to the liver or other parenchymal organs can occur, but this is very rare. The different organs metastases haven’t been described yet. The primary mode of treatment is radical surgical resection or debulking, followed by chemotherapy; however, patients with unresectable or recurrent GCC are candidates for systemic therapy. Here, we report a case of very aggressive GCC of the appendix, which had metastazed to the liver at the time of diagnosis and subsequently metastasized to the orbit.
Key words:
carcinoid tumor – goblet cells – metastatic – appendix – orbit
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.
Submitted:
2. 2. 2016
Accepted:
25. 4. 2016
Zdroje
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Štítky
Paediatric clinical oncology Surgery Clinical oncologyČlánok vyšiel v časopise
Clinical Oncology
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