Focal Affections of CNS in Patients with HIV Infection

Česká verzia

Authors: R. Černý ¹; J. Kapla ²; L. Machala ³
Authors place of work: Neurologická klinika dospělých 2. LF UK a FN v Motole, Praha ¹; Klinika infekčních nemocí LF UK a FN Hradec Králové ²; I. infekční klinika 2. LF UK a Klinika infekčních nemocí 3. LF UK, FN Na Bulovce, Praha ³
Published in the journal: Cesk Slov Neurol N 2010; 73/106(4): 374-378
Category: Review Article

Summary

Focal affections of the CNS are an important cause of morbidity and mortality in HIV-infected patients. HIV infection is rarely considered in patients with focal CNS symptomatology in the Czech Republic, a setting with low prevalence of HIV positivity. Nevertheless, delay in establishing a correct diagnosis has a negative influence on the patient’s prognosis and puts health-care workers at risk of infection. The most important causes of focal CNS affections in HIV-positive patients are: brain toxoplasmosis, primary CNS lymphoma, and progressive multifocal leuko-encephalopathy. The aetiology of other focal CNS affections in HIV-positive persons is similar to the situation in the normal population, but the incidence of these CNS affections in HIV-positive patients tends to be higher. A possible connection with HIV infection should be always taken in account, in order to establish a correct diagnosis as soon as possible, when the therapy can be most effective.

Key words:
HIV – focal CNS affections – brain toxoplasmosis – primary lymphoma

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