Dysembryoplastic Neuroepithelial Tumor and its Atypical Variant in Children – Case Reports

Česká verzia

Authors: D. Krahulík ¹; M. Vaverka ¹; L. Tučková ²; M. Köcher ³
Authors place of work: LF UP a FN Olomouc Neurochirurgická klinika ¹; LF UP a FN Olomouc Ústav klinické a molekulární patologie ²; LF UP a FN Olomouc Radiologická klinika ³
Published in the journal: Cesk Slov Neurol N 2013; 76/109(4): 492-496
Category: Case Report

Summary

In this short summary, the authors describe an atypical form of dysembryoplastic neuroepithelial tumor (DNET) in children that has a different clinical, radiological and cytological profile that the typical DNET. Epileptic seizures with good response to radical surgical resection are the main clinical feature of a typical DNET. These tumors are typically in frontal or temporal locations. We describe three patients who underwent surgery during the last eight months, including a girl with an atypical form of DNET presenting with atypical clinical and, mainly, cytogenetic findings.

Key words:
neuroepithelial tumors – atypical forms

Zdroje

1. Daumas-Duport C, Scheithauer BW, Chodkiewicz JP, Laws ER jr, Vedrenne C. Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. Report of thirty- nine cases. Neurosurgery 1988; 23(5): 545– 556.

2. Kaye AH, Laws E jr (eds). Brain tumors: an encyclopedic approach. 2nd ed. New York: Churchill Livingstone 2001.

3. Campos AR, Clusmann H, von Lehe M, Niehusmann P, Becker AJ, Schramm J et al. Simple and complex dysembryoplastic neuroepithelial tumors (DNT) variants: clinical profile, MRI, and histopathology. Neuroradiology 2009; 51(7): 433– 443.

4. Ostertun B, Wolf HK, Campos MG, Matus C, Solymosi L, Elger CE et al. Dysembryoplastic neuroepithelial tumors: MR and CT evaluation. AJNR Am J Neuroradiol 1996; 17(3): 419– 430.

5. Urbach H. MRI of long‑term epilepsy‑associated tumors. Semin Ultrasound CT MR 2008; 29(1): 40– 46.

6. Raymond AA, Halpin SF, Alsanjari N, Cook MJ, Kitchen ND, Fish DR et al. Dysembryoplastic neuroepithelial tumor. Features in 16 patients. Brain 1994; 117(3): 461– 475.

7. Hamada H, Kurimoto M, Nagai S, Asahi T, HirashimaY, Endo S. A rare case of dysembryoplastic neuroepithelial tumour in occipital lobe presenting with only headache. J Clin Neurosci 2003; 10(2): 276– 278.

8. Bird- Lieberman G, Sethi K, Childs AM, Chumas P, Crimmins D, Ismail A et al. Diffuse hemispheric dysembryoplastic neuroepithelial tumor: a new radiological variant associated with early- onset severe epilepsy. J Neurosurg Pediatr 2011; 7(4): 416– 420.

9. Parmar HA, Hawkins C, Ozelame R, Chuang S, Rutka J,Blaser S. Fluid- attenuated inversion recovery ring sign as a marker of dyembryoplastic neuroepithelial tumors. J Comput Assist Tomogr 2007; 31(3): 348– 353.

10. Hamada H, Kurimoto M, Nagai S, Asahi T, Hirashima Y, Endo S. A rare case of dysembryoplastic neuroepithelial tumour in occipital lobe presenting with only headache. J Clin Neurosci 2003; 10(2): 276– 278.

11. Quarato PP, Gennaro GD, Manfredi M, Esposito V.Atypical Lennox- Gastaut syndrome successfully treated with removal of a parietal dysembryoplastic tumour. Seizure 2002; 11(5): 325– 329.

12. Drake J, Hoffman HJ, Kobayashi J, Hwang P, Becker LE. Surgical management of children with temporal lobe epilepsy and mass lesions. Neurosurgery 1987; 21(6): 792– 797.

13. Nolan MA, Sakuta R, Chuang N, Otsubo H, Rutka JT,Snead OC 3rd et al. Dysembryoplastic neuroepithelial tumors in childhood: long‑term outcome and prognostic features. Neurology 2004; 62(12): 2270– 2276.

14. Luyken C, Blümcke I, Fimmers R, Urbach H, Elger CE,Wiestler OD et al. The spectrum of long‑term epilepsy‑associated tumors: long‑term seizure and tumor outcome and neurosurgical aspects. Epilepsia 2003; 44(6): 822– 830.