Nanoparticle-based Drug Delivery Systems Crossing Blood-brain Barrier – Hope for Future Treatment of Neurodegenerative Disorders?

Česká verzia

Authors: M. Filipová ¹; R. Rusina ^2,3; K. Holada ¹
Authors place of work: Ústav imunologie a mikrobiologie, 1. LF UK v Praze ¹; Neurologická klinika a Centrum klinických neurověd, 1. LF UK a VFN v Praze ²; Neurologické oddělení, Thomayerova nemocnice v Praze ³
Published in the journal: Cesk Slov Neurol N 2016; 79/112(2): 160-167
Category: Review Article

Práce vznikla za přispění grantu Ministerstva školství mládeže a tělovýchovy ČR (Kontakt II – LH12014) a Ministerstva zdravotnictví ČR (IGA MZ NT 14145-3).
Poděkování patří Dr. Janu Šimákovi a Dr. Silvii Lacerdě (CBER, FDA, White Oak, USA) za pomoc s konfokální mikroskopií a přípravou fluorescenčně značených M60COOH.

Summary

Due to the continually rising prevalence and lack of effective therapy, neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease, are among the most serious problems of modern medicine. Even though promising compounds with potential therapeutic effect have been developed, blood-brain barrier impedes their transport to the central nervous system. Nanotechnologies produce particles with properties that enable them to cross the blood-brain barrier and thus provide hope in solving this problem. Wide utilization of nanoparticles for transportation of drugs is prevented by our limited knowledge of their biological properties and their safety profile. Further developments in this field together with increasing understanding of the pathogenesis of neurodegeneration may lead to development of effective therapy in the future.

Key words:
blood-brain barrier – dendrimers – liposomes – nanotubes – carbon – nanoparticles – neurodegenerative diseases

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

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