Reaching the inferior fronto-occipital fascicle with the help of Klingler dissection and DTI tractography

Česká verzia

Authors: E. Neuman ¹; O. Šandor ²; M. Hána ²; M. Keřkovský ³; M. Joukal ²; M. Smrčka ¹
Authors place of work: Neurochirurgická klinika FN Brno ¹; Anatomický ústav, LF MU Brno ²; Klinika radiologie a nukleární, medicíny FN Brno ³
Published in the journal: Cesk Slov Neurol N 2021; 84/117(2): 139-150
Category: Original Paper
doi: https://doi.org/10.48095/cccsnn2021139

Summary

Aim: The aim of this study is to provide both image sources and a verbal description to allow the mental visualization of the course of the inferior fronto-occipital fascicle (IFOF) when looking at the brain from the lateral side, and to highlight the clinical importance of this associative white matter tract. Methods: In the three hemispheres of the brains of deceased donors, the IFOF was dissected using the Klingler method, with the aim to preserve as many intact cortical structures as possible. The spared cortical structures of the brain are good reference points for orientation on the brain surface. Diffusion tensor imaging (DTI) tractography was performed as another method to study the anatomical course of the IFOF. The data for the tractography were obtained using MRI examination in a healthy volunteer. Results: It was possible to dissect the IFOF in all three hemispheres. The course of the IFOF was documented in photographs of the dissections. Similarly, the course of the IFOF is depicted through the use of tractographic reconstructions and projections of these reconstructions in the MRI image of the brain. Both methods provide very similar results when it comes to IFOF anatomy. Conclusion: The availability of neuronavigation or other technological instruments did not reduce the need for knowledge of anatomy. The authors hope that the results presented in this project can serve to expand one’s knowledge or at least to awaken an interest in anatomy.

Keywords:

human brain anatomy – white matter – fiber dissection – Diffusion tensor imaging – Tractography – inferior fronto-occipital fasciculus – semantic system

Zdroje

1. Sporns O, Tononi G, Kötter R. The human connectome: a structural description of the human brain. PLoS Comput Biol 2005; 1(4): e42. doi: 10.1371/ journal.pcbi.0010042.

2. Duffau H. Brain plasticity: from pathophysiological mechanisms to therapeutic applications. J Clin Neurosci 2006; 13(9): 885–897. doi: 10.1016/ j.jocn.2005.11.045.

3. Ius T, Angelini E, Thiebaut de Schotten M et al. Evidence for potentials and limitations of brain plasticity using an atlas of functional resectability of WHO grade II gliomas: towards a „minimal common brain“. Neuroimage 2011; 56(3): 992–1000. doi: 10.1016/ j.neuroimage.2011.03.022.

4. Ludwig E, Klingler J. Atlas cerebri humani. Basel, N.Y.: Karger 1956.

5. Forkel SJ, Thiebaut de Schotten M, Kawadler JM et al. The anatomy of fronto-occipital connections from early blunt dissections to contemporary tractography. Cortex 2014; 56: 73–84. doi: 10.1016/ j.cortex.2012.09.005.

6. Curran E. A new association fibre tract in the cerebrum. With remarks of the fibre tract dissection method of studying the brain. J Compar Neurol Psychology 1909; 19(6): 1e18.

7. Catani M, Howard RJ, Pajevic S et al. Virtual in vivo interactive dissection of white matter fasciculi in the human brain. Neuroimage 2002; 17(1): 77–94. doi: 10.1006/ nimg.2002.1136.

8. Schmahmann JD, Pandya DN, Wang R et al. Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography. Brain 2007; 130(Pt 3): 630–653. doi: 10.1093/ brain/ awl359.

9. Catani M. From hodology to function. Brain 2007; 130(Pt 3): 602–605. doi: 10.1093/ brain/ awm008.

10. Sarubbo S, Petit L, De Benedictis A et al. Uncovering the inferior fronto-occipital fascicle and its topological organization in non-human primates: the missing connection for language evolution. Brain Struct Funct 2019; 224(4): 1553–1567. doi: 10.1007/ s00429-019-01856-2.

11. FLS. [online]. Available from URL: https:/ / fsl.fmrib.ox.ac.uk/ fsl/ fslwiki/ .

12. medInria. [online]. Available from URL: https:/ / med.inria.fr.

13. Weinstein D, Kindlmann G, Lundberg E. Tensorlines: advection-diffusion based propagation through diffusion tensor fields. San Francisco, CA, USA: Institute of Electrical and Electronics Engineers 1999: 249–530.

14. 3D Slicer. [online]. Available from URL: https:/ / www.slicer.org/ .

15. NITRC. [online]. Available from URL: https:/ / www.nitrc.org/ .

16. Ribas, G. The cerebral architecture. In: Ribas, G. Applied cranial-cerebral anatomy: brain architecture and anatomically oriented microneurosurgery. Cambridge: Cambridge University Press 2018: 15–61.

17. Martino J, Brogna C, Robles SG et al. Anatomic dissection of the inferior fronto-occipital fasciculus revisited in the lights of brain stimulation data. Cortex 2010; 46(5): 691–699. doi: 10.1016/ j.cortex.2009.07.015.

18. Sarubbo S, De Benedictis A, Maldonado IL et al. Frontal terminations for the inferior fronto-occipital fascicle: anatomical dissection, DTI study and functional considerations on a multi-component bundle. Brain Struct Funct 2013; 218(1): 21–37. doi: 10.1007/ s00429 011 0372-3.

19. Párraga RG, Ribas GC, Welling LC et al. Microsurgical anatomy of the optic radiation and related fibers in 3-dimensional images. Neurosurgery 2012; 71 (1 Suppl Operative): 160–172. doi: 10.1227/ NEU.0b013e3182556fde.

20. Duffau H, Gatignol P, Mandonnet E et al. New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations. Brain 2005; 128(Pt 4): 797–810. doi:10.1093/ brain/ awh423.

21. Lambon Ralph MA. Neurocognitive insights on conceptual knowledge and its breakdown. Philos Trans R Soc Lond B Biol Sci 2013; 369(1634): 20120392. doi: 10.1098/ rstb.2012.0392.

22. Moritz-Gasser S, Herbet G, Duffau H. Mapping the connectivity underlying multimodal (verbal and non-verbal) semantic processing: a brain electrostimulation study. Neuropsychologia 2013; 51(10): 1814–1822. doi: 10.1016/ j.neuropsychologia.2013.06.007.

23. Herbet G, Moritz-Gasser S, Duffau H. Direct evidence for the contributive role of the right inferior fronto-occipital fasciculus in non-verbal semantic cognition. Brain Struct Funct 2017; 222(4): 1597–1610. doi: 10.1007/ s00429-016-1294-x.

24. Duffau H. Miami global brain tumor symposium – Dr. Hugues Duffau. [online]. Available from URL: https:/ / www.youtube.com/ watch?v=Lool6cpkCkc.

25. Rollans C, Cummine J. One tract, two tract, old tract, new tract: a pilot study of the structural and functional differentiation of the inferior fronto-occipital fasciculus. J Neurolinguist 2018; 46: 122–137. doi: 10.1016/ j.jneuroling.2017.12.009.

26. Yordanova YN, Duffau H, Herbet G. Neural pathways subserving face-based mentalizing. Brain Struct Funct 2017; 222(7): 3087–3105. doi: 10.1007/ s00429-017-1388-0.

27. Herbet G, Duffau H. Revisiting the functional anatomy of the human brain: toward a meta-networking theory of cerebral functions. Physiol Rev 2020; 100(3): 1181–1228. doi: 10.1152/ physrev.00033.2019.

28. Fernández-Miranda JC, Rhoton AL Jr, Alvarez-Linera J et al. Three-dimensional microsurgical and tractographic anatomy of the white matter of the human brain. Neurosurgery 2008; 62 (6 Suppl 3): 989–1028. doi: 10.1227/ 01.neu.0000333767.05328.49.

29. Bartoš R, Hejčl A, Zolal A et al. Laboratorní disekce drah laterálního aspektu mozkové hemisféry. Cesk Slov Neurol N 2012; 75/ 108(1): 30–37.

30. Hejčl A, Bartoš R, Zolal A et al. Laboratorní preparace drah z mediálního pohledu na mozkovou hemisféru. Cesk Slov Neurol N 2012; 75/ 108(6): 707–713.

31. Bartoš R, Concepción S. IJ, Němcová V et al. Průvodce mozkem. Neuroanatomie. Praha: Maxdorf 2020.