Median nerve pathology in acromegaly

Česká verzia

Authors: I. Ságová ^1,2; P. Vaňuga ¹; D. Pávai ¹; D. Kantárová ²; D. Holováčová ³; E. Huľo ⁴; M. Mokáň ²; J. Payer ⁵; P. Letavay ⁶
Authors place of work: Endokrinologické oddelenie, Národný endokrinologický a diabetologický ústav Ľubochňa, Slovensko ¹; 1. interná klinika UN a JLFUK, Martin, Slovensko ²; I. Interná klinika LF UK a UNB, Bratislava, Slovensko ³; Oddelenie všeobecnej a úrazovej chirurgie, Nemocnica Spišská Nová Ves ⁴; V. interná klinika LFUK a UNB, Bratislava, Slovensko ⁵; Interné oddelenie, Dolnooravská NsP MUDr. L. Nádaši Jégého, Dolný Kubín, Slovensko ⁶
Published in the journal: Cesk Slov Neurol N 2022; 85(3): 235-238
Category: Original Paper
doi: https://doi.org/10.48095/cccsnn2022235

Summary

Aim: The aim of this study was to examine the cross-sectional area (CSA) of the median nerve using ultrasound in acromegalic patients and to assess the relationship between the CSA of the median nerve and the activity, duration of acromegaly and age of patients. Materials and methods: We prospectively examined the CSA of the median nerve in 107 acromegalic patients (70 women and 37 men) and in 77 healthy controls (51 women and 26 men) matched for age, sex and body mass index. The Student t-test and Pearson correlation were used for data analysis. Results: The CSA of the median nerve was significantly greater in acromegalic patients compared with healthy controls (0.12 ± 0.005 cm² vs. 0.078 ± 0.003 cm²; P < 0.001). The average duration of acromegaly was 11 years, average serum insulin-like growth factor 1 (IGF-1) level was 249.9 ng/mL and average growth hormone (RH) level was 2.63 ng/mL. We confirmed a positive correlation between the serum levels of IGF-1 and CSA of the median nerve in acromegalic patients (R = 0.400, P < 0.001). We did not confirm a relationship between CSA of the median nerve and serum levels of GH, duration of acromegaly and age of patients. Conclusion: In our study, we confirmed enlargement of the median nerve in patients with acromegaly. This enlargement depends on IGF-1 levels and is not depend on the duration of acromegaly and age of the patients.

Keywords:

Growth hormone – ultrasonography – acromegaly – insulin-like growth factor 1

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