A Study of Compressibility of the Directly Compacting Form of Lactitol

České info

Studium lisovatelnosti přímo lisovatelné formy laktitolu

Laktitol patří mezi cukerné alkoholy, které se používají jako suchá pojiva ve výrobě tablet, a topředevším tablet žvýkacích. Přímo lisovatelná forma této látky je vodou granulovaný laktitol. Prácese zabývá studiem lisovatelnosti granulované formy laktitolu a vlivem různé koncentrace mazadlastearanu hořečnatého na pevnost a dobu rozpadu výlisků z této látky. Laktitol nelze lisovat bezpřídavku mazadla. Stearan hořečnatý, použitý ve dvou koncentracích, a to 0,4 % a 0,8 %, nezasáhlnegativně do pevnosti výlisků. Doba rozpadu tablet se prodlužovala s rostoucí koncentrací stearanu,ale nezávisle na lisovací síle.

Klíčová slova:
přímé lisování – laktitol – stearan hořečnatý – pevnost tablet v tahu –doba rozpadu tablet

Authors: J. Mužíková
Authors‘ workplace: Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
Published in: Čes. slov. Farm., 2003; , 241-243
Category:

Overview

Lactitol ranks among sugar alcohols which are employed as dry binders in the manufacture oftablets, particularly the chewable ones.Water-granulated lactitol is the directly compacting form ofthis substance. The present paper studies the compressibility of the granulated form of lactitol andthe effects of different concentrations of the lubricant magnesium stearate on the strength anddisintegration time of the compacts from his substance. Lactitol cannot be compressed without anadded lubricant. Magnesium stearate, employed in two concentrations, 0.4 % and 0.8 %, did notnegatively interfere with the strength of the compacts. The disintegration period of tablets wasprolonged with increasing stearate concentration, but independently of compression force.

Key words:
direct compacting – lactitol – magnesium stearate – tensile strength of tablets –disintegration time of tablets

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Article was published in

Czech and Slovak Pharmacy

2003 Issue 5