Analysis of Tablets Containing the Antihistamine Loratadine: A Contribution to theIdentification of Impurities
Analýza tabliet s obsahom loratadínu (antihistaminikum)Príspevok k identifikácii nečistôt
Metódou chromatografie na tenkej vrstve silikagélu (Merck) sa sledovali nečistoty potenciálneprítomné v tabletách s obsahom liečiva loratadínu. Bola vypracovaná metóda, ktorú je možné použiťna sledovanie nečistôt. Je vhodnýmdoplnkomk stanoveniu obsahu loratadínu spektrofotometrickoumetódou v UV oblasti. Pre vybrané lieky bola metóda validovaná.
Klíčová slova:
loratadín – chromatografia na tenkej vrstve (TLC) – nečistoty – validácia
Authors:
N. Issa; M. Mlynárová
Authors‘ workplace:
Štátny ústav pre kontrolu liečiv, Bratislava
Published in:
Čes. slov. Farm., 2004; , 192-196
Category:
Overview
Thin-layer chromatography on silica gel (Merck) was employed to examine potential impuritiespresent in loratadine-containing tablets. A method usable for testing of impurities was elaborated,which suitably supplements the determination of loratadine content using the spectrophotometricmethod in the UV region. The method was validated for selected pharmaceuticals.
Key words:
laratadine – thin-layer chromatography (TLC) – impurities – validation
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2004 Issue 4
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