Technology of controlled-release tablets containing highly soluble active ingredients
Authors:
B. Vladovičová 1; V. Kormanová 1; M. Vítková 2; V. Hubinová 1; M. Žabka 2; K. Gardavská 2
Authors place of work:
Zentiva a. s., Hlohovec, Slovenská republika, 2Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra galenickej farmácie, Slovenská republika
1
Published in the journal:
Čes. slov. Farm., 2010; 59, 179-185
Summary
The aim of this experimental study was the preparation of once-daily-dosed matrix tablets containing the highly soluble drugs metoprolole succinate and metformine hydrochloride using Eudragit® NE 30 D as the matrix forming polymer. Matrix tablets were prepared by compression of coated granules. The formation of the secondary structure from the coating polymer was evaluated. In the case of metoprolole succinate, the drug release was prolonged, 53% of the drug being released within 20 hours. Dissolution profile was modified by addition of a filler, then the drug was completely released within 24 hours what is not acceptable for experimental purpose. The described technology of the preparation of the once-daily-dosed matrix was used also for the highly dosed drug metformine hydrochloride. The release rate of metformine hydrochloride was evaluated in dependence on the polymer content. The prepared formulation showed similar dissolution characteristics as the marketed product used in therapy. A positive effect of curing on the stability of the dissolution profile was demonstrated. The results demonstrate that the reported technology of compression of Eudragit® NE 30 D coated granules is usable for the preparation of prolonged-release dosage forms containing highly soluble drugs.
Key words:
Eudragit® NE 30 D – prolonged release – secondary structure – metoprolole succinate – metformine hydrochloride
Zdroje
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Štítky
Pharmacy Clinical pharmacologyČlánok vyšiel v časopise
Czech and Slovak Pharmacy
2010 Číslo 4
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