Mukoadhezivní filmy jako perspektivní lékové formy pro orální podání
Mukoadhezivní filmy jako perspektivní lékové formy pro orální podání
Mukoadheze představuje specifický proces vytváření vazeb během těsného kontaktu mezi biologickými povrchy pokrytými slizovou vrstvou a mukoadhezivním materiálem. V posledních letech vstupují do popředí zájmu farmaceutického průmyslu moderní lékové formy založené na tomto procesu. Filmy složené z mukoadhezivních polymerů (deriváty celulosy, polyakryláty, polyoxyethylen atd.) připravené některou ze zavedených metod (odpařování rozpouštědla, extruze taveniny atd.) mohou být perspektivními kandidáty pro orální aplikaci mnoha léků, především pro jejich flexibilitu a pohodlné použití. K dalším výhodám této lékové formy patří zlepšení relativně krátké doby setrvání konvenčních orálních lékových forem na sliznici a dodání přesné dávky léčiva na místo aplikace. Kromě toho mohou také překrytím chránit povrch slizniční léze, což napomáhá ke snížení bolestivosti a zlepšení účinnosti léčby. Cílem tohoto článku je poskytnout přehled o principech vzniku mukoadhezivních vazeb a o inovativní lékové formě – mukoadhezivních filmech z hlediska jejich složení, přípravy a praktického využití.
Klíčová slova:
sliznice dutiny ústní • principy mukoadheze • mukoadhezivní lékové formy • filmy • disky
Autoři:
Hana Landová; Zdeněk Daněk; Jan Gajdziok; David Vetchý; Jan Štembírek
Vyšlo v časopise:
Čes. slov. Farm., 2013; 62, 4-11
Kategorie:
Review Articles
Souhrn
Mukoadheze představuje specifický proces vytváření vazeb během těsného kontaktu mezi biologickými povrchy pokrytými slizovou vrstvou a mukoadhezivním materiálem. V posledních letech vstupují do popředí zájmu farmaceutického průmyslu moderní lékové formy založené na tomto procesu. Filmy složené z mukoadhezivních polymerů (deriváty celulosy, polyakryláty, polyoxyethylen atd.) připravené některou ze zavedených metod (odpařování rozpouštědla, extruze taveniny atd.) mohou být perspektivními kandidáty pro orální aplikaci mnoha léků, především pro jejich flexibilitu a pohodlné použití. K dalším výhodám této lékové formy patří zlepšení relativně krátké doby setrvání konvenčních orálních lékových forem na sliznici a dodání přesné dávky léčiva na místo aplikace. Kromě toho mohou také překrytím chránit povrch slizniční léze, což napomáhá ke snížení bolestivosti a zlepšení účinnosti léčby. Cílem tohoto článku je poskytnout přehled o principech vzniku mukoadhezivních vazeb a o inovativní lékové formě – mukoadhezivních filmech z hlediska jejich složení, přípravy a praktického využití.
Klíčová slova:
sliznice dutiny ústní • principy mukoadheze • mukoadhezivní lékové formy • filmy • disky
Zdroje
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Štítky
Pharmacy Clinical pharmacologyČlánok vyšiel v časopise
Czech and Slovak Pharmacy
2013 Číslo 1
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