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Formulation of benzethonium chloride into gels


Authors: Jozef Čižmárik;  Zuzana Vitková;  Petra Herdová;  Alexandra Kodadová;  Daniel Vími
Published in the journal: Čes. slov. Farm., 2014; 63, 123-126
Category: Original Articles

Summary

This study is focused on the preparation of gels with antimicrobial effects. A quaternary ammonium salt, benzethonium chloride, in a concentration of 0.01–0.5% (w/w) was employed as the drug. The humectant employed was propylene glycol in concentrations of 5% and 10% (w/w). Two types of polymers, chitosan and hydroxyethyl cellulose, in the same concentrations of 2.5% (w/w), were used for gel preparation. Finally the flow properties, rheological parameters and pH values of the gels were evaluated. Based on the obtained results, the samples of the gels prepared on the basis of chitosan and hydroxyethyl cellulose, which have the following optimum composition shown below, were found:

2,5% (w/w) CHIT + 0,5% (w/w) BZCl + 10% (w/w) PG;

2,5% (w/w) HEC + 0,5% (w/w) BZCl + 5% (w/w) PG.

Keywords:
benzethonium chloride • chitosan • hydroxyethyl cellulose • rheological properties


Zdroje

1. Borovanský A., Csőllei J. Farmaceutická chemie : (farmakochemie) VI. Léčiva s účinkem antiinfekčním a antiparazitárním. Brno: FaF VŠVF 2003. 294 s.

2. Cross, J., Singer, E.J. Cationic surfactants: analytical and biological evaluation. New York: Marcel Dekker Inc. 1994.

3. Gilbert P., Moore L. E. Cationic antiseptics: diversity of action under a common epithet. In: Journal of applied microbiology, 2005; 99(4), 703–715.

4. Lűllmann H., Mohr K., Wehling M. Farmakologie a toxikologie. 2.vyd. Praha: Grada Publishing 2004.

5. Aulton M. E. The Design and Manufacture of Medicine. 3. vyd. New York: Churchill Livingstone 2007.

6. NTP Toxicology and Carcinogenesis Studies of Benzethonium Chloride (CAS No. 121-54-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies). Natl Toxicol Program Tech Rep Ser. 1995; 438, 1–220. http://www.ncbi.nlm.nih.gov/pubmed/12595925 [cit. 12.5.2014]

7. Oremusová J., Vitková Z., Vitko, A. Study of micelle properties and thermodynamics of micellization of the benzethonium chloride. In: Tenside Surfactants Detergents 2012; 49(4), 322–329.

Štítky
Pharmacy Clinical pharmacology

Článok vyšiel v časopise

Czech and Slovak Pharmacy

Číslo 3

2014 Číslo 3

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