Schizophrenia in Childhood and Adolescence
Authors:
E. Malá
Authors place of work:
Psychiatrická ordinace, Neurologická klinika 1. LF UK, Praha
přednosta prof. MUDr. E. Růžička, DrSc.
Published in the journal:
Čes. a slov. Psychiat., 105, 2009, No. 5, pp. 212-217.
Category:
Comprehensive Reports
Summary
Schizophrenia is a disorder characterized by delay in neurodevelopment and by central disorder of recognition (i.e. with generalized cognitive deficit). The connectivity impairment in the area of social brain and cerebellum are the “messenger” of abnormal CNS development in schizophrenia. Processes of neuronal reorganisation in cortical and subcortical structures, aberrant forms of pruning, sprouting and myelinization may play a major role in the pathogenesis of a schizophrenic breakdown. Models of neuroplasticity during adolescence can be connected with models of neurodevelopmental vulnerability and models of neurotoxicity within an integrated approach in order to better understand premorbid adjustment, onset, and course of schizophrenic illness. The loss of plasticity and aberrant myelinization lead to the worsening of cognitive functions, social dysfunction and, in individuals with specific genetic vulnerability to expression of schizophrenia. This article discusses the brain development in relation to the schizophrenia diagnosis and basic symptoms of childhood schizophrenia (with early and very early onset) and of adolescence schizophrenia.
Key words:
childhood and adolescence schizophrenia, cognitive function, social brain, cerebellar cognitive affective syndrome, family trait marker of schizophrenia disorder.
Zdroje
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Štítky
Addictology Paediatric psychiatry PsychiatryČlánok vyšiel v časopise
Czech and Slovak Psychiatry
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