Oral Squamous Cell Carcinoma in the Annals of the Department of Dentistry in Hradec Králové
Authors:
V. Nováková 1; R. Slezák 1; J. Laco 2; L. Tuček 1; A. Ryška 2
Authors place of work:
Stomatologická klinika LF UK a FN, Hradec Králové
1; Fingerlandův ústav patologie LF UK a FN, Hradec Králové
2
Published in the journal:
Česká stomatologie / Praktické zubní lékařství, ročník 112, 2012, 2, s. 24-32
Category:
Original Article – Retrospective Essay
Summary
Introduction:
The incidence of head and neck cancer in Czech Republic is rising. Despite the recent advances in treatment which improve the quality of life of these patients, no significant drop in fatality of the disease has been noted in the last decades.
Aim:
The aim of the study was to describe the clinical and demographic characteristics and analyze the survival of a series of patients treated at the Department of Dentistry, Charles University Faculty of Medicine and University Teaching Hospital in Hradec Králové for oral squamous cell carcinoma in the period 1988–2008 and to compare the results to those of similar studies published in the Czech literature in the past.
Methods:
Two-hundred patients with oral squamous cell carcinoma diagnosed and treated at the Department of Dentistry were included in the study. Information about sex, age, site of the tumour, histologic findings, stage of disease, primary treatment method and cause of death were analyzed. The Kaplan-Meier method was used for survival analysis.
Results:
The median of follow up was 28 months (range 1–242 months). The male to female ratio was 2.1:1. The mean age of the patients was 62 ± 12 years. The most common areas affected by carcinoma were floor of mouth (51 cases, 26%) and lower lip (47 cases, 24%). One-hundred-and-one patients were diagnosed in the late stage of the disease (TNM stages III, IV). Most patients (87, 44%) were treated surgically. Seventy-seven patients (39%) experienced a locoregional recurrence. During the time of observation, 106 patients (53%) died, out of which 74 patients died of the primary malignant disease (37%). The 5-year overall survival was 45%, the 5-year disease-specific survival was 58%. The survival depended mostly on the site of the tumour (98% and 46% 5-year disease-specific survival for lip and intraoral carcinoma, respectively, p < 0.001) and on the stage of the disease. 5-year disease-specific survival was 91% for stage I, 73% for stage II, 46% for stage III, and 25% for stage IV disease (p < 0.001).
Conclusion:
One of the most important prognostic factors for oral squamous cell carcinoma is the stage of the disease, therefore, early diagnostics is essential. Examination of the oral cavity aimed at early detection of potentially malignant and malignant changes should be a part of every dental check up.
Key words:
mouth neoplasms – head and neck cancer – squamous cell carcinoma – survival
Zdroje
1. D’Souza, G., Kreimer, A. R., Viscidi, R., Pawlita, M., Fakhry, C., Koch, W. M., Westra, W. H. Gillison, M. L.: Case–Control Study of Human Papillomavirus and Oropharyngeal Cancer. N. Engl. J. Med., roč. 356, 2007, č. 19, s.1994–1956.
2. Guntinas-Lichius, O., Wendt, T., Buentzel, J., Esser, D., Lochner, P., Mueller, A., Schultze-Mosgau, S., Altendorf-Hofmann, A.: Head and neck cancer in Germany: a site-specific analysis of survival of the Thuringian cancer registration database. J. Cancer Res. Clin. Oncol., roč. 136, 2010, s. 55–63.
3. Chandu, A., Adams, G., Smith, C. H.: Factors affecting survival in patients with oral cancer: an Australian perspective. Int. J. Oral Maxillofac. Surg., roč. 34, 2005, s. 514–520.
4. Jebavý, Z.: Třicetileté zkušenosti s vyhledáváním a dispenzarizací zhoubných nádorů orofaciální oblasti na území okresu Kolín. Čes. Stomat., roč. 94, 1994, č. 6, s. 247–254.
5. Laco, J., Vošmiková, H., Nováková, V., a kol. The role of high-risk human papillomavirus infection in oral and oropharyngeal squamous cell carcinoma in non-smoking and non-drinking patients: a clinicopathological and molecular study of 46 cases. Virchows Arch., roč. 458, 2011, s. 179–187.
6. Llewellyn C. D., Linklater, K., Bell, J., Johnson, N. W., Warnakulasuriya K. A. A. S.: Squamous cell carcinoma of the oral cavity in patients aged 45 years and under: a descriptive analysis of 116 cases diagnosed in the South East of England from 1990 to 1997. Oral Oncol., roč. 39, 2003, s. 106–114.
7. Massano, J., Regateiro, F. S., Januário, G., Ferreira, A.: Oral squamous cell carcinoma: Review of prognostic and predictive factors. OOOOE, roč. 102, 2006, s. 87–76.
8. Novotvary 2007 ČR. Praha, Ústav zdravotnických informací a statistiky ČR ve spolupráci s Národním onkologickým registrem ČR, 2010, 262 s. ISBN 978-80-7280-849-6. Dostupný také na WWW: 9. Patel, S. G., Shah, J. P.: Results of treatment. In: Shah, J. P., Johnson, N. W., Batsakis, J. G. (eds.): Oral Cancer, Londýn, Martin Dunitz, 2003, s. 387–394.
10. Pitman, K. T., Johnson, J. T., Wagner, R. L., Myers, E. N.: Cancer of the tongue in patients less than forty. Head Neck, roč. 22, 2000, s. 297–302.
11. Podstata, J., Podstatová, H.: Epidemiologie maligních tumorů orofaciální oblasti. Čes. Stomat., roč. 80, 1980, č. 4, s. 297–303.
12. Rogers, S. N., Brown, J. S., Woolgar, J. A., et al. Survival following primary surgery for oral cancer. Oral Oncol., roč. 45, 2009, s. 201–211.
13. Sessions, D. G., Spector, G. J., Lenox, J., Haughey, B., Chao, C., Marks, J.: Analysis of Treatment Results for Oral Tongue Cancer. Laryngoscope, roč. 112, 2002, s. 616–625.
14. Šípková, K., Hájek, F.: Maligní nádory orofaciální oblasti léčené na lůžkovém oddělení. Čes. Stomat., roč. 83, 1983, č. 6, s. 436–441.
15. Škodová, Z., Cífková, R., Adámková, V., a kol. Vývoj kuřáckých zvyklostí obyvatelstva České republiky v období 1985–1997/98. Časopis lékařů českých, roč. 139, 2000, č. 5, s. 143–147.
16. Toman, J., Haisová, L., Mazánek, J.: Epidemiologická studie nemocných postižených rakovinou orofaciální oblasti léčených na I. stomatologické klinice v Praze v letech 1965-1979. Čes. Stomat., roč. 80, 1980, č. 6, s. 403–407.
17. Ušek, L., Mužík, J., Kubásek, M., Koptíková, J., Žaloudík, J., Vyzula, R.: Epidemiologie zhoubných nádorů v České republice [online]. Masarykova univerzita, [2005], [cit. 2011-6-10]. Dostupný z WWW: http://www.svod.cz. Verze 7.0 [2007], ISSN 1802 – 8861.
18. Warnakulasuriya, S., Mak, V., Möller, H.: Oral cancer survival in young people in South East England. Oral Oncol., roč. 43, 2007, s. 982–986.
Štítky
Maxillofacial surgery Orthodontics Dental medicineČlánok vyšiel v časopise
Czech Dental Journal
2012 Číslo 2
- What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?
- The Importance of Limosilactobacillus reuteri in Administration to Diabetics with Gingivitis
Najčítanejšie v tomto čísle
- Alveolar Bone Formation by Orthodontic Movement
- Oral Squamous Cell Carcinoma in the Annals of the Department of Dentistry in Hradec Králové
- The Effect of Surface Treatment on Composite Repair Bond Strength Longevity
- Effect of Macleaya Cordata (Willd )R.Br. Extract on Expression of Inflammatory Markers and Oxidative Stress in Gingival Fibroblasts