IgG antibodies against laminin-1 in serum and in peritoneal fluid in patients with decreased fertility
Authors:
R. Červená 1; K. Bibková 1; Z. Mičanová 1; B. Šedivá 2; Z. Ulčová-Gallová 1
Authors place of work:
Gynekologicko-porodnická klinika LF UK a FN Plzeň, přednosta doc. MUDr. Z. Rokyta, CSc.
1; Katedra matematiky, Fakulta aplikovaných věd, Západočeská Univerzita, Plzeň, vedoucí prof. RNDr. P. Drábek, DrSc.
2
Published in the journal:
Ceska Gynekol 2009; 74(3): 188-192
Summary
Objective:
To study of IgG antibodies against laminin-1 (IgG-a-Ln-1) in patients with decreased fertility, especially with endometriosis and with diagnosis of polycystic ovaries.
Design:
Prospective study.
Setting:
Special Consultation for Immunology of Reproduction and Research Laboratories for Reproductive Immunology, Department of Gynaecology and Obstetrics, Medical School of Charles University and Faculty Hospital, Pilsen.
Methods:
Commercial ELISA kits for detection of IgG antibodies against laminin-1 in serum (S) and peritoneal fluid (PF) in 120 patients after diagnostic laparoscopy, and in serum in 277 patients after 2-3 in vitro fertilizations and with diagnosed endometriosis.
Results:
Only 16 positive results in IgG-a-Ln-1 antibodies (more than 15 IU/ml ) were detected in sera and peritoneal fluids in the group of 120 women after laparoscopy.
We have not detected any serum IgG-a-Ln-1 positivity in the group of 277 patients after 2-3 unsuccesfull IVF and with anamnestical date about endometriosis together.
Conclusion:
Increased levels of IgG-a-Ln are in particular found in endometriosis Iľ-IIľ and in diagnosis of polycystic ovaries, in female diseases also related to autoimmune process.
Key words:
infertility, endometriosis, polycystic ovaries, IgG antibodies against laminin-1.
Zdroje
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Štítky
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineČlánok vyšiel v časopise
Czech Gynaecology
2009 Číslo 3
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