Cancer of endometrium - rare variant of remote metastases

Česká verzia

Authors: Luboš Minář ; D. Petrovová; J. Kümmel
Authors place of work: Gynekologicko-porodnická klinika LF MU a FN Brno, vedoucí pracoviště prof. MUDr. P. Ventruba, DrSc.
Published in the journal: Ceska Gynekol 2009; 74(5): 383-389

Summary

Objective:
Information sheet about cancer of endometrium as the most frequently gynecological malignant tumor.

Design:
Literature review with case reports.

Setting:
Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk’s University and Faculty Hospital, Brno.

Methods:
Literature review about cancer of endometrium with illustrative case reports.

Conclusions:
Cancer of endometrium is the most frequently malignant tumor of female reproductive organs in developed countries. Despite the absence of screening methods is almost 75% of cases diagnosed in stage I disease, which makes a good prognosis. Distant metastasis is less common, most frequently seen with a lung, but in the cencer of endoemtrium, as well as for malignant diseases in general, it is necessary to always count on is the possibility of their rare presentation. Management of cancer of endometrium is kept by oncogynecologist. Patients are divided into groups of forecasting low and high risk, while the therapeutic strategy is essential adequate radical operational solutions. In line with the trend of reduction radical solution and subsequent complications of surgical oncological studies are conducted on the possibility of detection of sentinel nodes, which hinted at a lack of data and experience, a complicating factor is also relatively complicated lymphatic drainage, body of the uterus. In terms of prevention, there are several ways to reduce the rising incidence of disease. In the context of primary prevention is the use of hormonal contraceptives. Also, women who use hormone replacement therapy, are detailed under medical supervision, which allows for early tumor states. Women with the accumulation of risk factors could benefit from simple diagnostic modalities (ie ultrasound, in particular), which in this case can be used for “limited screening”, resp. dispensary accurately high-risk patients. In primary prevention is the way the reduction of obesity. Research then turned to clarify the pathogenesis at the molecular level, the identification of new specific biomarkers that could help in early diagnosis and therapy. In the context of inherited disposition cancer of endometrium is then appropriate to focus on the relevant risk group of patients with accumulation of cancer of endometrium and colorectal cancer in a personal and family history, which are then indicated to the genetic consultation and possibly mutation analysis.

Key words:
cancer of endometrium, histological types, pathogenesis, risk factors, dissemination of tumor, therapy options.

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