Proteomics and biomarkers for detection of cervical cancer

Česká verzia

Authors: M. Kacerovský; J. Tošner
Authors place of work: Lékařská fakulta Hradec Králové Univerzita Karlova Praha, Porodnická a gynekologická klinika FN Hradec Králové, přednosta doc. MUDr. J. Tošner, CSc.
Published in the journal: Ceska Gynekol 2009; 74(5): 335-338

Summary

Objective:
The purpose of this study was to focus on recent developments in the rapidly evolving field of biomarker discovery and validation techniques using proteomics platform with respect to cervical cancer.

Design:
Review.

Setting:
Department of Obstetrics and Gynecology Medical Faculty Charles University Hradec Kralove.

Methods:
The last decade has seen major changes in the technologies used to identify diagnostic markers for early stages of cervical cancer. Significant advances were achieved in three key areas: protein profilling, multidimensional liquid chromatography combined with cutting edge mass spectrometry and high-throughput validation techniques. These new technologies hold significant promise in identifying more robust, sensitive and specific markers for cervical cancer.

Conclusion:
The present review summarizes the results of clinical and experimental research on biomarkers of cervical cancer.

Key words:
proteomics, cervical cancer, biomarker.

Zdroje

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