Innate immunity in pathogenesis of intraamniotic inflammation in pregnancies complicated by preterm premature rupture of membranes

Česká verzia

Authors: E. Flídrová; J. Krejsek
Authors place of work: Ústav klinické imunologie a alergologie, Lékařská fakulta Hradec Králové a Fakultní nemocnice, Hradec Králové, UK Praha, přednosta prof. RNDr. J. Krejsek, CSc.
Published in the journal: Ceska Gynekol 2011; 76(1): 46-50

Summary

Objective:
To give an overview about the role of the innate immunity in pathogenesis of intraamniotic inflammation in pregnancies complicated by preterm premature rupture of membranes.

Design:
Review article.

Setting:
Department of Clinical Immunology and Allergy, Faculty of Medicine and University Hospital in Hradec Kralove, Charles University in Prague.

Method:
An overview of recent published data.

Conclusion:
Immune system has an indisplaceable function throughout the successful pregnancy. Spontaneous labor is the result of many factors in which innate immunity playes a major role. The increased concentrations of proinflammatory markers (interleukin (IL)-1beta, IL-6, tumour necrosis factor alfa a IL-8) were found in amniotic fluid both in term and in preterm spontaneous delivery. These markers could be used for an early diagnosis of intraamnial infection/inflammation, which is the most common cause of preterm delivery (PTD) and preterm premature rupture of membranes (PPROM). The elevation of these markers could also better determine the patients with enhanced probability of PTD and PPROM.

Key words:
amniochorion, amniotic fluid, innate immunity, intraamniotic inflammation, preterm premature rupture of membranes, proinflammatory markers.

Zdroje

1. Abrahams, VM., Bole-Aldo, P., Kim, YM., et al. Divergent trophoblast responses to bacterial products mediated by TLRs. J Immunol, 2004, 173(7), p. 4286-4296.

2. Arntzen, KJ., KjŅllesdal, AM., Halgunset, J., et al. TNF, IL-1, IL-6, IL-8 and soluble TNF receptors in relation to chorioamnionitis and premature labor. J Perinat Med, 1998, 26(1), p. 17-26.

3. Belt, AR., Baldassare, JJ., Molnár, M., et al. The nuclear transcription factor NF-kappaB mediates interleukin-1beta-induced expression of cyclooxygenase-2 in human myometrial cells. Am J Obstet Gynecol, 1999, 181(2), p. 359-366.

4. Cahill, RJ., Tan, S., Dougan, G., et al. Universal DNA primers amplify bacterial DNA from human fetal membranes and link Fusobacterium nucleatum with prolonged preterm membrane rupture. Mol Hum Reprod, 2005, 11(10), p. 761-766.

5. Condon, JC., Jeyasuria, P., Faust, JM., Mendelson, CR. Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition. Proc Natl Acad Sci U S A, 2004, 101(14), p. 4978-4983.

6. DiGiulio, DB., Romero, R., Amogan, HP., et al. Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. PLoS One, 2008, 3(8), p. e3056.

7. Fortunato, SJ., Menon, R. Distinct molecular events suggest different pathways for preterm labor and premature rupture of membranes. Am J Obstet Gynecol, 2001, 184(7), p. 1399-1405.

8. Gewirtz, AT., Navas, TA., Lyons, S., et al. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol, 2001, 167(4), p. 1882-1885.

9. Ghezzi, F., Franchi, M., Raio, L., et al. Elevated amniotic fluid C-reactive protein at the time of genetic amniocentesis is a marker for preterm delivery. Am J Obstet Gynecol, 2002, 186(2), p. 268‑273.

10. Goldenberg, RL., Culhane, JF., Iams, JD., Romero, R. Epidemiology and causes of preterm birth. Lancet, 2008, 5, p. 75-84.

11. Goldenberg, RL., Hauth, JC., Andrews, WW. Intrauterine infection and preterm delivery. N Engl J Med, 2000, 342(20), p. 1500-1507.

12. Holst, RM., Laurini, R., Jacobsson, B., et al. Expression of cytokines and chemokines in cervical and amniotic fluid: relationship to histological chorioamnionitis. J Matern Fetal Neonatal Med, 2007, 20(12), p. 885-893.

13. Houben, ML., Nikkels, PG., van Bleek, GM., et al. The association between intrauterine inflammation and spontaneous vaginal delivery at term: a cross-sectional study. PLoS One, 2009, 4(8), p. e6572.

14. Kacerovsky, M., Drahosova, M., Hornychova, H., et al. Value of amniotic fluid interleukin-8 for the prediction of histological chorioamnionitis in preterm premature rupture of membranes. Neuro Endocrinol Lett, 2009, 30(6), p. 733-738.

15. Kacerovský, M., Drahošová, M., Hornychová, H., et al. Interleukin 6 v plodové vodě pacientek s předčasným odtokem plodové vody. Čes Gynek, 2009, 74, 6, s. 403-410.

16. Kacerovsky, M., Tosner, J., Drahosova, M., et al. Pentraxin 3 in amniotic fluid as a marker of intra-amniotic inflammation in women with preterm premature rupture of membranes. Int J Gynaecol Obstet, 2010, 108, p. 203-206.

17. Kim, YM., Romero, R., Chaiworapongsa, T., et al. Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis. Am J Obstet Gynecol, 2004, 191(4), p. 1346-1355.

18. Laar, R., Ham, DP., Oei, SG., et al. Accuracy of C-reactive protein determination in predicting chorioamnionitis and neonatal infection in pregnant women with premature rupture of membranes: a systematic review. Eur J Obstet Gynecol Reprod Biol, 2009, 147(2), p. 124-129.

19. Maymon, E., Romero, R., Pacora, P., et al. Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection. Am J Obstet Gynecol, 2000, 183(1), p. 94-99.

20. Maymon, E., Romero, R., Pacora, P., et al. Evidence of in vivo differential bioavailability of the active forms of matrix metalloproteinases 9 and 2 in parturition, spontaneous rupture of membranes, and intra-amniotic infection. Am J Obstet Gynecol, 2000, 183(4), p. 887-894.

21. Patni, S., Synem, LP., Sester, AL., et al. Expression and activity of toll-like receptors 1–9 in the human term placenta and changes associated with labor at term. Biol Reprod, 2009, 80(2), p. 243‑248.

22. Pitiphat, W., Gillman, MW., Joshipura, KJ., et al. Plasma C-reactive protein in early pregnancy and preterm delivery. Am J Epidemiol, 2005, 162(11), p. 1108-1113.

23. Pollard, JK., Mitchell, MD. Effects of gestational age on prostaglandin production and its regulation in human myometrial cells. J Matern Fetal Med, 1996, 5(2), p. 93-98.

24. Rauk, PN., Friebe-Hoffmann, U., Winebrenner, LD., Chiao, JP. Interleukin-6 up-regulates the oxytocin receptor in cultured uterine smooth muscle cells. Am J Reprod Immunol, 2001, 45(3), p. 148-153.

25. Redline, RW. Inflammatory responses in the placenta and umbilical cord. Semin Fetal Neonatal Med, 2006, 11(5), p. 296‑301.

26. Roh, CR., Oh, WJ., Yoon, BK., Lee, JH. Up-regulation of matrix metalloproteinase-9 in human myometrium during labour: a cytokine-mediated process in uterine smooth muscle cells. Mol Hum Reprod, 2000, 6(1), p. 96-102.

27. Rovere-Querini, P., Antonacci, S., Dell’Antonio, G., et al. Plasma and tissue expression of the long pentraxin 3 during normal pregnancy and preeclampsia. Obstet Gynecol, 2006, 108, p. 148-155.

28. Shimoya, K., Taniguchi, T., Matsuzaki, N., et al. Chorioamnionitis decreased incidence of respiratory distress syndrome by elevating fetal interleukin-6 serum concentration. Hum Reprod, 2000, 15(10), p. 2234-2240.

29. Smith, R. Parturition. N Engl J Med, 2007, 356(3), p. 271-283.

30. Zaga-Clavellina, V., Garcia-Lopez, G., Flores-Herrera, H., et al. In vitro secretion profiles of interleukin (IL)-1beta, IL-6, IL-8, IL-10, and TNF alpha after selective infection with Escherichia coli in human fetal membranes. Reprod Biol Endocrinol, 2007, 5, p. 46.