Thrombin generation test at physiological and risk gravidity

Česká verzia

Authors: V. Lattová ¹; M. Procházka ¹; J. Úlehlová ²
Authors place of work: Porodnicko-gynekologická klinika FN, Olomouc, přednosta prof. MUDr. R. Pilka, Ph. D. ¹; Hemato-onkologická klinika FN, Olomouc, přednosta prof. MUDr. K. Indrák, DrSc. ²
Published in the journal: Ceska Gynekol 2011; 76(5): 367-370

Summary

Generation of thrombin is pivotal step of hemostasis, according to in vitro experiments, thrombin generation occurs in 2 phases. Initially small amount of thrombin is produced after activation of factor X by complex TF / FVIIa. Thrombin multiplies coagulation by activation of platelets, F V a F VIII. Complex of TF / FVIIa activates also F VIII a, F IX, F VIII and FIXa and its binding to surface of platelets, which activates F X and products quantity of thrombin and leads formation of fibrin and finaly to triggering clotting.

Design:
Review.

Setting:
Department of Obstetrics and Gynecology, University Hospital Olomouc.

Key words:
thrombin generation test, gravidity, coagulation.

Zdroje

1. Castodi, E., Rosing, J. Trombin generation test, Tromb Res, 2011, 127, Suppl. 3, S21-S25.

2. Hellgren, M. Hemostasis dutinng normal pregnancy and puerperium, Semin Tromb Hemost, 2003, 29 (2), p. 125-130.

3. Hemker, HC., Giesen, P,. Aldieri, R., et al. The Calibrated Autamated Thrombogram (CAT): a universal routine tets for hyper- and hypocoagulability. Pathophysiol Heamostatis Trombosis, 2002, 3, 2, p. 249-253.

4. Procházka, M., Procházková, J., Lubušký, M., Slavík, L. Trombofilní stavy v porodnictví, I. část. Prakt Gynek, 2004, 4, p. 12-16.