Triple negative breast cancer – prognostically highly unfavourable group cancer of breast

Česká verzia

Authors: Luboš Minář ¹ ; M. Hvizdová ¹; Vít Weinberger ¹ ; E. Jandáková ²
Authors place of work: Gynekologicko-porodnická klinika LF MU a FN Brno, přednosta prof. MUDr. P. Ventruba, DrSc. ¹; Ústav patologie LF MU a FN Brno, přednosta doc. MUDr. J. Feit, CSc. ²
Published in the journal: Ceska Gynekol 2012; 77(2): 132-138
Category: Original Article

Summary

Objective:
Presentation of the file prognostically highly unfavourable group cancers of breast.

Design:
Retrospective analysis.

Setting:
Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University and Faculty Hospital, Brno.

Methods:
In the study, we retrospectively analyzed 47 patients with triple negative breast cancer, who have undergone in the period 2005–2008 complete treatment and then follow-up in Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University and Faculty Hospital, Brno. 2/3 patients underwent primary surgery followed by adjuvant therapy, 1/3 patients underwent neoadjuvant chemotherapy followed by surgery and eventually adjuvant therapy. Then patients were transferred to follow-up.

Results:
Approximatelly 2/3 patients were diagnosed in early stages I and IIA FIGO, other patients in advanced stages, even though almost 90% of women participated regularly in mammography screening. With neoadjuvant chemotherapy was achieved complete pathological remission in 15% patients, in 70% patients reduction volume of the tumor at least 50%, other patients were resistant to chemotherapy. Recurrence of disease was detected by almost 39% of patients on condition follow-up at least 30 months after completion of primary treatment. Patients, who were diagnosed and treated in early stages, suffered more frequently from local recurrence and interval of recurrence from completion of primary treatment was longer. Patients, who were diagnosed and treated in advanced stages, suffered more frequently from remote metastasis and interval of recurrence from completion primary treatment was shorter.

Conclusion:
Triple negative cancers of breast are highly aggressive tumors with poor prognosis. They often are associated with lymphadenopathy and characterized by frequent occurrence of local recurrences and high risk of remote metastases. These tumors represent a large part of so-called interval cancers. Tumors often occurs in young women with BRCA1 mutations. Elementary systemic treatment is chemotherapy. Together continues the effort of highly targeted therapy, based on new findings in genomics and proteomics and on detection of many markers expressed by this version of breast cancer.

Key words:
triple negative cancer of breast, surgical treatment, neoadjuvant chemotherapy, lymphadenopathy, remote metastasis, recurrence.

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