Blockade of calcium channels – a perspectiveof male contraception?

Česká verzia

Authors: D. Driák ¹ ; I. Švandová ²
Authors place of work: Gynekologicko-porodnická klinika 1. LF UK a Nemocnice Na Bulovce, Praha, přednosta prof. MUDr. M. Halaška, DrSc. ¹; Katedra fyziologie, Přírodovědecká fakulta UK, Praha ²
Published in the journal: Ceska Gynekol 2013; 78(2): 216-220

Summary

Besides condoms and vasectomy with their own limitations, no other reliable methods of contraception are available to men. Ion channels play a key role in maturation, capacitation and acrosome reaction of sperms. Blockade of calcium channels with pharmacological inhibitors or compounds isolated from plant extracts might be suggested as one of promising mechanisms of future male contraceptives.

Keywords:
male contraception – calcium channels – blockade

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