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Autoimmune anti-N-methyl-D-aspartate receptor encephalitis – paraneoplastic syndrome of ovarian teratoma


Authors: Benická A. 1;  Pilka R. 1;  Flodr P. 2
Authors place of work: Porodnicko-gynekologická klinika LF UP a FN Olomouc 1;  Ústav klinické a molekulární patologie, LF UP a FN Olomouc 2
Published in the journal: Ceska Gynekol 2021; 86(6): 397-399
Category: Case Report
doi: https://doi.org/10.48095/cccg2021397

Summary

Objective: Case presentation and subsequent dia­gnostic and therapeutic procedure of autoimmune encephalitis caused by the presence of ovarian teratoma. Case report: We describe the case of a young woman with symptoms of an acute psychotic attack unresponsive to antipsychotic treatment. Anti-N-methyl-D-aspartate receptor encephalitis was dia­gnosed within the interdisciplinary cooperation at the University Hospital in Olomouc. Conclusion: This type of rare and potentially fatal paraneoplastic limbic encephalitis occurs predominantly in young women. Due to the high variability of neuropsychiatric symptoms, the dia­gnosis of the disease is very difficult, and therefore patients are often primarily incorrectly treated for other neurological or psychiatric diseases. The most prognostically important part is early dia­gnosis and adequate therapy.

Keywords:

paraneoplastic syndrome – ovarian teratoma – anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDAR encephalitis)


Zdroje

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Štítky
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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