The role of the microbiome in pregnancy
Authors:
Hornová M.; Pařízek A.; Koucký M.
Authors place of work:
Gynekologicko-porodnická klinika 1. LF UK a VFN v Praze
Published in the journal:
Ceska Gynekol 2021; 86(6): 422-427
Category:
Review Article
doi:
https://doi.org/10.48095/cccg2021422
Summary
Objective: To provide a comprehensive overview of the available information on the maternal microbiome and its effect on pregnancy and preterm birth. Methods: Systematic review of available literature on the topic was done using the PubMed database. Conclusion: Etiology of preterm labor is multifactorial. Individual setting of humoral and cellular immune response is key; however, lately the focus has shifted to the role of the microbiome, especially the vaginal one. The role of additional microbiomes and the relationship between different compartments are the focus of intensive research. Mainly the differences in the maternal and neonatal microbiome depend on the method of delivery and administration of different antibiotics during pregnancy and labor. The uterine cavity is no longer thought to be without colonization and the formation of the fetal microbiome begins early in pregnancy.
Keywords:
Preterm labor – microbiome – antibiotics – microbial invasion of amniotic cavity – vaginal seeding
Zdroje
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Štítky
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineČlánok vyšiel v časopise
Czech Gynaecology
2021 Číslo 6
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