Syphilis and HIV Coinfection
Authors:
Z. Rozehnalová 1; J. Hercogová 1; D. Jilich 2; L. Machala 2; H. Rozsypal 2
Authors place of work:
Dermatovenerologická klinika UK 2. LF a FN Na Bulovce, Praha
přednostka prof. MUDr. Jana Hercogová, CSc.
1; Infekční klinika UK 2. LF a FN Na Bulovce, Praha
Přednostka doc. MUDr. Vilma Marešová, CSc.
2
Published in the journal:
Čes-slov Derm, 84, 2009, No. 5, p. 278-283
Category:
Venereology
Summary
In majority of HIV positive patients, syphilis is manifested in the same way as in HIV negative ones, however, this combination might alter the course of both infections. HIV infection might accelerate the course of syphilis and on the contrary syphilis could cause HIV infection progression. Article monitors the alteration of syphilis clinical course in HIV positive patients, points out the pitfalls of serologic diagnosis and evaluates the effectivity of treatment regimens.
Key words:
syphilis – HIV infection – coinfection syphilis/HIV – serology –therapy
Zdroje
1. Augenbraun, M. Workowski, K. Ceftriaxone therapy for syphilis: report from the emerging infections network. Clin Infect Dis, 1999, 29, p. 1337-8.
2. BOLAN, G. Syphilis and HIV. HIV In Site Knowledge Base Chapter, 1998, May, p. 1-20.
3. Brown, ST. Zaidi, A. Larsen, SA. Serological response to syphilis treatment. A new analysis of old data. JAMA, 1985, 253, p. 1296-9.
4. BUCHACZ, K. GREENBERG, A. ONORATO, I. Syphilis epidemics and human immunodeficiency virus (HIV) incidence among men who have sex with men in United States: implications for HIV prevention. Sex Transm Dis, 2005, 32 (10), p. 73-9.
5. BUTT, M. NANDWANI, R. Sexually transmitted diseases in HIV-1-infected patiens. Lancet, 2001, 357, p. 1533.
6. CARMO, AR. MOURA, SA. CHRISTO, P. Syphilitic meningitis in HIV-patients with meningeal syndrome. Braz j. Infect Dis, 2001, 5 (5), p. 280-287.
7. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines 2002. MMWR Recomm Rep, 2002, 51, p. 1-78.
8. FLOOD, JM. WEINSTOCK, HS. GUROY, ME. Neurosyphilis during the AIDS epidemic, San Francisco, 1985-1992. J Infect Dis 1998, 177, p. 931-40.
9. FUNNYE, AS. AKHTAR, AJ. Syphilis and human immunodeficiency virus co-infection. J Natl med Assoc, 2003, 95 (5), p. 363-82.
10. GOLDEN, R. MARRA, Ch. HOLMES, K. Update on syphilis: resurgence of an old problem. JAMA, 2003, 290 (11), p. 1510-1514.
11. GOUREVITCH, MN. SELWYN, PA. DAVENNY, K. Effects of HIV infection on the serologic manifestations and response to treatment of syfilis in intravenous drug users. Ann Intern Med, 1993, 118 (5), p. 350-5.
12. Gregory, N. Sanchez, M. Buchness, MR. The spectrum of syphilis in patients with human immunodeficiency virus infection. J Am Acad Dermatol, 1990, 22, p. 1061-7.
13. Guinan, ME. Treatment of primary and secondary syphilis: defining failure at three- and six- month follow-up. JAMA, 1987, 257, p. 359-60.
14. HALL, S. Ch., KLAUSNER, D. J., BOLAN, A. G. Managing syphilis in the HIV-infected patient. Curr Infect Dis Rep, 2004, 6, p. 72-82.
15. Hicks, CB. Benson, PM. Lupton, GP. Seronegative secondary syphilis in a patient infected with the human immunodeficiency virus (HIV) with Kaposi sarcoma. A diagnostic dilemma. Ann Intern Med, 1987, 107, p. 492-5.
16. Hook, EW. Martin, DH. Stephens, J. A randomized, comparative pilot study of azithromycin versus benzathine penicillin G for treatment of early syphilis. Sex Transm Dis, 2002, 29, p. 486-90.
17. HUTCHINSON, CM. HOOK, EW. SHEPHERD, M. HIV and the presentation of early syphilis. Ann Intern Med, 1994, 121, p. 94-99.
18. JAY, CA. Treatment of neurosyphilis. Curr Treat Options Neurol, 2006, 8 (3), p. 185-92.
19. Kuklová, I. Kojanová, M. Velčevský, P. Současný stav problematiky sexuálně přenosných onemocnění, Čes-slov Derm, 2008, 83 (3), p. 115-121.
20. KURUMUDI, UR. AUGENBRAUN, M. Syphilis and HIV: a dangerous duo. Expert Rev Anti Infect Ther, 2005, 3 (5), p. 825-31.
21. Lukehart, SA. Godornes, C. Molini, BJ. Macrolide resistance in Treponema pallidum in the United States and Ireland. N Engl J Med, 2004, 351, p. 154-8.
22. Marra, CM. Boutin, P. McArthur, JC. A pilot study evaluating ceftriaxone and penicillin G as treatment agents for neurosyphilis in human immunodeficiency virus-infected individuals. Clin Infect Dis, 2000, 30, p. 540-4.
23. MARRA, CM. TANTALO, LC. MAXWELL, CL. Alternative cerebrospinal fluid tests to diagnose neurosyphilis in HIV-infected individuals. Neurology, 2004, 63 (1), p. 85-8.
24. MARRA, Ch. Syphilis, Human immunodeficiency virus, and the nervous system. AIDS and the Nervous System, 1997, Philadelphia, p. 677-690.
25. Mitchel, SJ. Engelman, J. Kent, CK. Azithromycin-resistant syphilis infection: San Francisco, California, 2000-2004. Clin Infect Dis, 2006.
26. MUSHER, DM. HAMILL, RJ. BAUGHN, RE. Effect of human immunodeficiency virus (HIV) infection on the course of syphilis and on the response to treatment. Ann Intern Med, 1990, 113 (11), p. 872-81.
27. PODWINSKA, J. Syphilis and AIDS. Arch immunol Ther Exp, 1996, 44 (5-6), p. 329-33.
28. Riedner, G. Rusizoka, M. Todd, J. Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis. N Engl J Med, 2005, 353, p. 1236-44.
29. Rolfs, RT. Joesoef, MR. Hendershot, EF. A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group. N Engl J Med, 1997, 337, p. 307-14.
30. Schofer, H. Imhof, M. Thoma-Greber, E. Active syphilis in HIV infection: a multicentre retrospective survey. The German AIDS Study Group (GASG). Genitourin Med, 1996, 72, p. 176-81.
31. Smith, ME. Canalis, RF. Otologic manifestations of AIDS: the otosyphilis connection. Laryngoscope, 1989, 99, p. 365-72.
32. Smith, NH. Musher, DM. Huang, DB. Response of HIV-infected patients with asymptomatic syphilis to intensive intramuscular therapy with ceftriaxone or procaine penicillin. Int J STD AIDS, 2004, 15, p. 328-32.
33. TAYLOR, M. HAWKINS, K. GONZALEZ, A. Use of the serologic testing algorithm for recent HIV seroconversion (STARHS) to identify recently acquired HIV infections in men with early syphilis in Los Angeles county. J Acquir Immune Defic Syndr, 2005, 38 (5), p. 505-508.
34. Tucker, SC. Yates, VM. Thambar, IV. Unusual skin ulceration in an HIV-positive patient who had cutaneous syphilis and neurosyphilis. Br J Dermatol, 1997, 136, p. 946-8
35. Velčevský, P. Kuklová, I. Léčba sexuálně přenosných onemocnění, Čes-slov Derm, 2008, 83 (3), p. 123-135.
36. STÁTNÍ ZDRAVOTNÍ ÚSTAV ČESKÉ REPUBLIKY NRL pro AIDS HIV/AIDS v ČR 2007. Praha, 2008.
Štítky
Dermatology & STDs Paediatric dermatology & STDsČlánok vyšiel v časopise
Czech-Slovak Dermatology
2009 Číslo 5
Najčítanejšie v tomto čísle
- Syphilis and HIV Coinfection
- Primary Cutaneous Actinomycosis in Two Patients Treated with Clindamycin
- Cutaneons Metastasis as a Primary Manifestation of a Renal Cell Carcinoma
- Diabetic Foot Syndrome – a Diabetologist’s View