Up-to-date Situation with Gonorrhoea:
Prague STI Center Results – Antimicrobial Susceptibility Monitoring

Česká verzia

Authors: M. Kojanová ¹; I. Kuklová ¹; M. Slováčková ²; J. Běláček ³; J. Štork ¹
Authors place of work: Dermatovenerologická klinika 1. LF UK a VFN, Praha přednosta prof. MUDr. Jiří Štork, CSc. ¹; Ústav lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN, Praha přednosta prof. MUDr. Tomáš Zima, DrSc., MBA ²; Ústav biofyziky a informatiky 1. LF UK přednosta prof. MUDr. RNDr. Jiří Beneš, CSc. ³
Published in the journal: Čes-slov Derm, 89, 2014, No. 5, p. 240-248
Category: Venereology

Summary

The year 2012 in the Czech Republic experienced a dramatic increase in the number of gonorrhoea cases of 67.1% over the prior year.

In recent years we have been witnessing worsening situation due to the decreased effects of antimicrobial medication on Neisseria gonorrhoeae and, at the same time, a growth in the number of new HIV infections.

In the course of our monitoring gonorrhoea patients, the STI Centre of the Dermatovenereology Clinic of the First Faculty of Medicine, Charles University and General Teaching Hospital in Prague has found a greater incidence of resistance to antimicrobial medication. Data from the period 2006 – 2010 and 2012 – 2013, show increased resistance to azithromycin from 3.9% to 22.9 %, respectively. Resistance to cefotaxim increased from 0.6% to 10.0%, and to penicilin from 86.5% to 100.0%; while resistance to ciprofloxacin (from 71.3% to 68.6%) and tetracyklin (from 80.3 % to 71,4 %) did not increase during this period, resistance levels remained exceptionally high. There is a statistical evidence that the nature and application of antibiotic therapy in the Czech Republic have not substantially changed in recent years.

Our article presents an overview of findings regarding HIV and gonorrhoea in the Czech Republic ad demonstrates the correlation of their transmissions, depicts the changes in sensitivity of gonorrhoea to antimicrobial medication, and presents guidelines for treatment.

It is shown that the monitoring of the epidemiological occurrence of gonorrhoea and related effective therapy helps prevent the spread of HIV infections.

Key words:
STI – gonorrhoea – N. gonorrhoeae – MSM – resistance – HIV

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