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Gastroesophageral reflux in pre-term infants: 24hour multichannel intraluminal impedance/pH metry


Authors: R. Vyhnánek 1;  E. J. Olafsdottir 2;  P. Koťátko 1;  D. Marková 1;  M. Hladíková 1;  P. Szitányi 1;  P. Frühauf 1
Authors place of work: Klinika dětského a dorostového lékařství 1. LF UK a VFN, Praha přednosta prof. MUDr. J. Zeman, DrSc. 1;  Department of Pediatrics, Haukeland Universtiy Hospital, Bergen, Norsko Head prof. B. Skadberg M. D., Ph. D. 2
Published in the journal: Čes-slov Pediat 2011; 66 (3): 141-145.
Category: Original Papers

Summary

Aims:
The aim of our study was to evaluate 24-hour multichannel intraluminal impedance pH monitoring measurements in originally preterm infants, and also to compare different parameters that either depend or are independent from pH of the refluxate.

Methods:
Twenty six infants, rectruited from The Follow-up clinic of The Department of Pediatric and Adolescent Medicine of the First Medical Faculty of The Charles University and General University Hospital in Prague, have been evaluated at corrected age of 3 to 45 weeks, median 13 weeks, median of gestational age 29 weeks.

We used the Bolus Exposure Index to evaluate the significance of impedance measurement, with cut-off value of 1.4, as other authors in the past, even though the value has not been generally recognized in this group of children. For pH monitoring we used the generally recognized Boix-Ochoa Index of 16.6 as our cut-off value.

Results:
The examination showed prevalence of gastroesophageal reflux of 69.9% using impedance and 57.5% using pH in this group of infants. That corresponds to prevalence in otherwise healthy term infants as stated in the literature. Number of reflux episodes and Bolus Exposure Index, and also Bolus Exposure Index and Boix-Ochoa index correlate significantly.

Conclusion:
Prevalence of GER in our group of infants corresponds to that in otherwise healthy term infants. Statistically significant difference between impedance and pH in diagnosing GER has not been shown, correlation to symptoms is necessary however to evaluate the benefit of the methods used.

Key words:
impedance, pH metry, preterm infant, gastroesophageal reflux


Zdroje

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Štítky
Neonatology Paediatrics General practitioner for children and adolescents
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