Favourable prognosis of solitary kidney in children?
Authors:
G. Koľvek 1; Ľ. Podracká 2
Authors place of work:
Klinika detí a dorastu, LF UPJŠ a DFN, Košice
1; I. detská klinika LFUK a DFNsP, Bratislava
2
Published in the journal:
Čes-slov Pediat 2015; 70 (5): 282-286.
Category:
Original Papers
Summary
This study aims to assess the cumulative incidence of elevated albuminuria, hypertension and decreased estimated glomerular filtration rate (eGFR) to identify possible renal injury in children with SFK. Forty-two children with SFK (23 boys; 27 congenital) were included in a prospective follow-up study. Blood pressure, albuminuria and eGFR were assessed repeatedly and the cumulative incidence rate of various forms of renal injury, overall and by type of etiology, were evaluated. Finally, renal injury-free survival was analyzed. Mean follow-up was until age 11.3 years (SD 6.3 years). During follow-up, 16/42 (38.1%) patients met the criteria for renal injury, defined as hypertension (10/42; 23.8%), severely increased albuminuria (3/42; 7.1%) and a significantly impaired eGFR (<60 ml/min/1.73 m2) (5/42; 11.9%) and/or use of antihypertensive or antiproteinuric medication (11/42; 26.2%). Children with CAKUT in SFK had a significantly higher incidence of renal injury. The median time to develop renal injury was 12.8 years.
Conclusion:
A substantial proportion of children with SFK develop renal injury during childhood, especially those with CAKUT in the SFK. Therefore, close follow-up of albuminuria, blood pressure and eGFR are warranted to identify chronic kidney disease in its early stages.
Key words:
albuminuria, children, glomerular filtration rate, hypertension, solitary kidney
Zdroje
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Štítky
Neonatology Paediatrics General practitioner for children and adolescentsČlánok vyšiel v časopise
Czech-Slovak Pediatrics
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