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Tolerogenic dendritic cells and their application in immunopathological processes


Authors: A. Grohová 1,2,3;  K. Dáňová 1,2;  L. Palová-Jelínková 1
Authors place of work: SOTIO, a. s., Oddělení výzkumu, Praha 1;  Ústav imunologie 2. LF UK a FN Motol, Praha 2;  Pediatrická klinika 2. LF UK a FN Motol, Praha 3
Published in the journal: Čes-slov Pediat 2017; 72 (4): 256-262.
Category: Review

Summary

Tolerogenic dendritic cells (tDC) are specific group of dendritic cells. At steady-state they are located in diverse tissue and play a pivotal role in maintaining central and peripheral immune tolerance. tDC restore and maintain immune homeostasis by inhibition of antigen-specific T-lymphocytes, induction of T-regulatory cells as well as B-regulatory cells and production of anti-inflammatory cytokines. tDC due to their ability to down-regulate immune response are promising tool to re-establish antigen-specific tolerance in autoimmune diseases without adverse effects of systemic immunosuppression. This interventional strategy also offers an interesting way to treat other immunopathological processes.

Key words:
tolerogenic dendritic cells, cellular therapy, immune tolerance, autoimmune disease


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Štítky
Neonatology Paediatrics General practitioner for children and adolescents
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