Protein concentration in human milk after preterm delivery
Authors:
I. Burianová 1,4; J. Malý 2; M. Navratilova 2; E. Tichá 2; V. Vítková 1,3; J. Kudláčková 1; B. Zlatohlávková 5; E. Vokurková 5; K. Boráková 6; T. Brožová 6; M. Pánek 7; J. Pánková 7; L. Kantor 8; I. Vránová 8; J. Bronský 4
Authors place of work:
Novorozenecké oddělení s JIP, Thomayerova nemocnice, Praha
1; Dětská klinika LF UK a FN, Hradec Králové
2; Ústav patologické fyziologie 1. LF UK, Praha
3; Pediatrická klinika 2. LF UK a FN Motol, Praha
4; Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha
5; Ústav péče o matku a dítě, Praha
6; Novorozenecké oddělení, Krajská zdravotní a. s., Ústí nad Labem
7; Novorozenecké oddělení FN, Olomouc
8
Published in the journal:
Čes-slov Pediat 2017; 72 (8): 472-477.
Category:
Original Papers
Summary
Aim of study:
To evaluate the amount of protein in a set of human milk samples using mid-infrared human milk analyser after preterm labour during the first two months of lactation.
Methods:
Analysis of the donated milk samples between 24+0 and 35+6 gestational age (GA) was designed as prospective observational cohort trial. Two milk samples were analysed up to the discharge from the hospital, week 9 or loss of lactation. Analysis was performed using the MIRIS Human Milk Analyser (MIRIS AB, Uppsala, Sweden).
Results:
Total of 1917 human milk samples donated by 225 mothers after preterm labour were analysed. Group A (24–30 GA) contained 969 milk samples, the group B (31–35 GA) contained 948 milk samples. Mean true protein content decreased from 1.72 g/dL in group A and 1.65 g/dL in group B at the end of the first week of life to 1.1 g/dL in both groups at the end of the week 3, and remained stable with mean values around 1.0 g/dL up to week 9.
Conclusion:
There was no difference in the protein content of human milk as a function of term of premature delivery. Moreover the protein content was lower than expected and even decreased during first three weeks of lactation. We did not detect a significant difference in milk protein levels between group A (24–30 GA) and group B (31–35 GA).
Key words:
human milk, macronutrients, protein, premature birth
Zdroje
1. American Academy of Pediatrics. Breast feeding and the use of human milk. Pediatrics 2012; 129: e827–e841.
2. Agostini C, Buonocore G, Carnielli V, et al. Enteral nutrient supply for preterm infants: commentary from the European Society for Paediatric Gastroenterology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 2010; 50: 1–9.
3. Underwood MA. Human milk for premature infant. Pediatr Clin North Am 2013; 60: 189–207.
4. Vohr BR, Poindexter B, Wrage L, et al. Persistent beneficial effects of breast milk ingested in the neonatal intensive care unit on outcomes of extremely low birth weight infants at 30 months of age. Pediatrics 2007; 120: e953–959.
5. Ehrenkrantz RA, Dusick AM, Vohr BR, et al. Growth in the neonatal intensive care unit influences neurodevelopmental and growth outcomes of extremely low birtg weight infants. Pediatrics 2006; 117: 1253–1261.
6. Isaacs EB, Morley R, Lucas A. Early diet and general cognitive outcome at adolescence in children born below 30 weeks of gestation. J Pediatr 2009; 155: 229–234.
7. Singhal A, Cole TJ, Lucas A. Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials. Lancet 2001; 357: 413–419.
8. Lucas A, Morley R, Cole TJ, et al. Breast milk and subsequent intelligence quotient in children born preterm. Lancet 1992; 339: 261–264.
9. Saarela T, Kokkonen J, Koivisto M. Macronutrient and energy content of human milk fractions during the six months of lactation. Acta Paediatr 2005; 94: 1176–1181.
10. Wojcik KY, Retchman DJ, Lee ML, et al. Macronutrient analysis of a nationwide sample of donor breast milk. J Am Diet Assoc 2009; 109: 137–140.
11. Cooper AR, Barnett D, Gentles E, et al. Macronutrient content of donor human breast milk. Arch Dis Child Fetal Neonatal Ed 2013; 98: F539–F541.
12. Bauer J, Gerss J. Longitudinal analysis of macronutrients and minerals in human milk produced by mothers of preterm infants. Clin Nutr 2011; 30: 215–220.
13. Zachariassen G, Fenger-Gron J, Hviid MV, Halken S. The content of macronutrients in milk from mothers of very preterm infants is highly variable. Dan Med J 2013; 60 (6): A4631.
14. Gidrewicz DA, Fenton TR. A systematic review and meta-analysis of the nutrient content of preterm and term breast milk. BMC Pediatrics 2014; 14: 216–229.
15. Embleton NE, Pang N, Cooke RJ. Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants? Pediatrics 2001; 107: 270–273.
16. Sentere T, Rigo J. Reduction of postnatal cumulative nutritional deficit and improvement of growth in extremely preterm infants. Acta Paediatr 2012; 101: e64–e70.
17. Griffin IJ, Tancredi DJ, Bertino E, et al. Postnatal growth failure in very low birthweight infants born between 2005 and 2015. Arch Dis Child Fetal Neonatal Ed 2016; 101: F50–F55.
18. Rochow N, Fusch G, Choi A, et al. Target fortification of breast milk with fat, protein, and carbohydrates for preterm infants. J Pediatr 2013; 163: 1001–1007.
19. Fusch G, Mitra S, Rochow N, Fusch C. Target fortification of breast milk: levels of fat, protein or lactose are not related. Acta Paediatr 2015; 104: 38–42.
20. Rochow N, Fusch G, Zapanta B, et al. Target fortification of breast milk: how often should milk analysis be done? Nutrients 2015; 7: 2297–2310.
21. Gomella TL, Cunningham MD, Eyal FG. Neonatology. 6th ed. McGraw Hill Companies, Inc. 2009.
22. Gross SJ, Geller J, Tomarelli RM. Composition of breast milk from mothers of preterm infants. Pediatrics 1981; 68 (4): 490–493.
23. Faerk J, Skafte L, Petersen S, et al. Macronutrients in milk from mothers delivering preterm. Adv Exp Mol Biol 2001; 501: 409–413.
24. Silvestre D, Fraga M, Gormaz M, et al. Comparison of mid-infrared transmission spectroscopy with biochemical methods for the determination of macronutrients in human milk. Matern Child Nutr 2014; 10: 373–382.
25. Fusch G, Rochow N, Choi A, et al. Rapid measurement of macronutrients in breast milk: how reliable are infrared milk analyzers? Clin Nutr 2015; 34: 465–476.
Štítky
Neonatology Paediatrics General practitioner for children and adolescentsČlánok vyšiel v časopise
Czech-Slovak Pediatrics
2017 Číslo 8
- What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?
- The Importance of Limosilactobacillus reuteri in Administration to Diabetics with Gingivitis
Najčítanejšie v tomto čísle
- Thalassemias
- Chronic otitis media in childhood
- Brain abscess – a rare but a serious infection in childhood
- Thalassemias and hemoglobin variants in children