Systemic lupus erythematosus with hematological symptoms – a multifaceted disease: case reports and summary for clinical practice

Česká verzia

Authors: K. Bouchalova ¹; H. Flögelová ¹; P. Horák ²; M. Skácelová ²; D. Dvořák ¹; M. Schüller ³; D. Pospíšilová ¹
Authors place of work: Dětská klinika, Fakultní nemocnice a Lékařská fakulta Univerzity Palackého, Olomouc ¹; III. interní klinika NRE, Fakultní nemocnice a Lékařská fakulta Univerzity Palackého, Olomouc ²; Pediatrická klinika, Lékařská fakulta, Masarykova univerzita a Fakultní nemocnice Brno ³
Published in the journal: Čes-slov Pediat 2021; 76 (6): 304-312.
Category: Original Papers

Summary

Systemic lupus erythematosus (SLE) is a severe highly heterogenous multisystemic inflammatory disease, characterized by a combination of clinical and immunological criteria.

The aim of a paper is to show variability of clinical and hematological findings, that could be first symptoms of developing SLE and might precede diagnosis by different time ranging from weeks to many years. These findings encompasses immune thrombocytopenic purpura (ITP), autoimmune hemolytic anemia, and asymptomatic strong positivity of anticardiolipine antibodies, which lasted from one month to 7 years in our patients. We highlight an importance of early assessment of autoantibodies in patients with these hematologic diseases and need for a deep collaboration between hematologist and rheumatologist, which is a quarantee of early SLE diagnosis and therapy initiation.

Keywords:

arthritis – Systemic lupus erythematosus – Hemolytic anemia – therapy – diagnostics – 2019 EULAR/ACR classification criteria – SLICC classification criteria – antiphospholipid antibodies – immune thrombocytopenic purpura

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