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Regulation of energy balance and eating behaviour


Authors: Lebl Jan 1;  Malíková Křenek Jana 1;  Hainerová Aldhoon Irena 2,3
Authors place of work: Pediatrická klinika, 2. lékařská fakulta UK, a Fakultní nemocnice v Motole, Praha 1;  Klinika dětí a dorostu, 3. lékařská fakulta UK, a Fakultní nemocnice Královské, Vinohrady, Praha 2;  Pediatrická klinika, 1. lékařská fakulta UK, a Fakultní Thomayerova, nemocnice, Praha 3
Published in the journal: Čes-slov Pediat 2023; 78 (1): 48-53.
Category: Childhood Obesity Epidemic
doi: https://doi.org/10.55095/CSPediatrie2023/009

Summary

Energy balance and eating behaviour are regulated by leptin-melanocortin system that includes afferent signals from peripheral tissues (leptin, ghrelin, insulin, blood glucose), integrative first order neurons in arcuate nucleus, and second order effector neurons in paraventricular and intermediolateral nuclei that express melanocortin receptors. Components of this system have individual genetic and epigenetic coding, with partial impact of environmental factors. Abnormal eating behaviour may be due to pathogenic variants of genes encoding key molecules of eating behaviour. Monogenic obesity is characterized by early-onset obesity – in some cases with insulin resistance and/ or neurodevelopmental delay.

Keywords:

obesity – energy balance – gut microbiome – eating behaviour – monogenic obesity – basal thermogenesis


Zdroje

1. Poitou C, Mosbah H, Clément K. Mechanisms in endocrinology: Update on treatments for patients with genetic obesity. Eur J Endocrinol 2020; 183(5): R149–R166

2. McDermott L. Self-representation in upper paleolithic female figurines. Current Anthropology 1996; 37(2): 227–75.

3. Styne DM, Arslanian SA, Connor EL, et al. Pediatric obesity-assessment, treatment, and prevention: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2017; 102(3): 709–57.

4. El-Sayed Moustafa JS, Froguel P. From obesity genetics to the future of personalized obesity therapy. Nat Rev Endocrinol 2013; 9(7): 402–13.

5. Hainerová IA, Lebl J. Mechanisms of appetite regulation. J Pediatr Gastroenterol Nutr 2010; 51 Suppl 3: S123–4.

6. Geserick M, Vogel M, Gausche R, et al. Acceleration of BMI in early childhood and risk of sustained obesity. N Engl J Med 2018; 379: 1303–12.

7. Farooqi IS, O’Rahilly S. Mutations in ligands and receptors of the leptin- -melanocortin pathway that lead to obesity. Nat Clin Pract Endocrinol Metab 2008; 4(10): 569–77.

8. Allison MB, Myers Jr MG. 20 years of leptin: connecting leptin signaling to biological function. J Endocrinol 2014; 223(1): T25–35.

9. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334(5): 292–5.

10. Kühnen P, Krude H, Biebermann H. Melanocortin-4 receptor signalling: importance for weight regulation and obesity treatment. Trends Mol Med 2019; 25(2): 136–48.

11. Yang LK, Tao YX. Biased signaling at neural melanocortin receptors in regulation of energy homeostasis. Biochim Biophys Acta Mol Basis Dis 2017; 1863(10 Pt A): 2486–95.

12. Gjesing AP, Larsen LH, Torekov SS, et al. Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity. PLoS One 2010; 5(4): e10084.

13. Hainerová I, Larsen LH, Holst B, et al. Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis. J Clin Endocrinol Metab 2007; 92(9): 3689–96.

14. Vollbach H, Brandt S, Lahr G, et al. Prevalence and phenotypic characterization of MC4R variants in a large pediatric cohort. Int J Obes 2017; 41(1): 13–22.

15. Hainerová IA, Lebl J. Treatment options for children with monogenic forms of obesity. World Rev Nutr Diet 2013; 106: 105–12.

16. Farooqi IS, Keogh JM, Yeo GSH, et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 2003; 348(12): 1085–95.

17. Gonsalves R, Aleck K, Newbern D, et al. Severe early onset obesity and hypopituitarism in a child with a novel SIM1 gene mutation. Endocrinol Diabetes Metab Case Rep 2020; 2020: 20-0042.

18. Podyma B, Parekh K, Güler AD, et al. Metabolic homeostasis via BDNF and its receptors. Trends Endocrinol Metab 2021; 32(7): 488–99.

19. Giannopoulou EZ, Zorn S, Schirmer M, et al. Genetic obesity in children: overview of possible diagnoses with a focus on SH2B1 deletion. Horm Res Paediatr 2022; 95(2): 137–48.

20. Berruien NNA, Smith CL. Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology. Gene 2020; 757: 144949.

21. Guo L, Costanzo-Garvey DL, Smith DR, et al. Kinase suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis. Mol Metab 2016; 6(2): 194–205.

22. Cho KY. Lifestyle modifications result in alterations in the gut microbiota in obese children. BMC Microbiol 2021; 21(1): 10.

23. Koutoukidis DA, Jebb SA, Zimmerman M, et al. The association of weight loss with changes in the gut microbiota diversity, composition, and intestinal permeability: a systematic review and meta-analysis. Gut Microbes 2022; 14(1): 2020068.

24. Barber TM, Bhatti AA, Elder PJD, et al. AMY1 gene copy number correlates with glucose absorption and visceral fat volume, but not with insulin resistance. J Clin Endocrinol Metab 2020; 105(10): dgaa473.

25. Claussnitzer M, Dankel SN, Kim KH, et al. FTO obesity variant circuitry and adipocyte browning in humans. Engl J Med 2015; 373(10): 895–907.

Štítky
Neonatology Paediatrics General practitioner for children and adolescents
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