Epidemiological aspects of selected respiratory viruses in children with recurrent respiratory infections
Authors:
Kunč Peter 1,3; Fábry Jaroslav 2; Ferenc Peter 1; Pešátová Monika 1; Matiščáková Michaela 1; Péčová Renata 3
Authors place of work:
Národný ústav detskej, tuberkulózy a respiračných, chorôb n. o., Dolný Smokovec
1; Klinika detskej tuberkulózy, a respiračných chorôb, Jesseniova lekárska fakulta, Univerzita Komenského, a Národný ústav detskej, tuberkulózy a respiračných, chorôb n. o., Dolný Smokovec
2; Ústav patologickej fyziológie, Jesseniova lekárska fakulta, Univerzita Komenského, Martin
3
Published in the journal:
Čes-slov Pediat 2024; 79 (5): 286-292.
Category:
Original Papers
doi:
https://doi.org/:10.55095/CSPediatrie2024/032
Summary
Introduction: Respiratory viruses contribute significantly to respiratory morbidity in children with a high burden on society.
Objectives: Retrospective analysis of the epidemiological characteristics of selected respiratory viruses detected in often ill pediatric patients.
Materials and methods: Assessment of laryngeal swab outcomes. The results were examined using RT-PCR method for a coherent group of 10 viruses: rhinovirus (RV), adenovirus (ADV), respiratory syncytial virus (RSV), human coronavirus (HCoV), parainfluenza virus (PIV 1-4), human bocavirus (HboV), and human metapneumovirus (HMPV). The data collection period was established from January 2022 to June 2023. This period corresponded to the investigation of 722 samples. The variables analysed included age, sex, month of detection of the pathogen, and diagnosis of acute respiratory infection. The average age of the children was 5.6 ± 4.3 years.
Results: Among all samples, more than half (373; 52%) were confirmed to contain a viral pathogen. The virus with the highest prevalence was RV (184; 49%). ADV was the second most prevalent (47; 12%), closely followed by respiratory RSV (40; 11%). An analysis of virus detection over different months revealed typical epidemiological patterns, with RV and ADV present throughout the year, and RSV, PIV 1-4, and HMPV showing seasonal patterns. The two most common viruses, RV and RSV, exhibited a differential age-related presence in children.
Conclusion: This study found that the prevalence of specific respiratory viruses varies according to the season and age of paediatric patients with acute respiratory infections. By identifying specific pathogens, we can enhance therapeutic management and prevent possible complications of viral respiratory infections.
Keywords:
Epidemiology – Respiratory syncytial virus – children – respiratory viruses – acute respiratory infections – rhinovirus
Zdroje
1. Moreira ALE, da Silva PAN, Assunção L do P, et al. Profile analysis of emerging respiratory virus in children. Eur J Clin Microbiol Infect Dis 2023; 42(7): 873–82.
2. Taylor S, Lopez P, Weckx L, et al. Respiratory viruses and influenza-like illness: Epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample. J Infect 2017; 74(1): 29–41.
3. De Conto F, Conversano F, Medici MC, et al. Epidemiology of human respiratory viruses in children with acute respiratory tract infection in a 3-year hospital-based survey in Northern Italy. Diagn Microbiol Infect Dis 2019; 94(3): 260–7.
4. Brealey JC, Sly PD, Young PR, Chappell KJ. Viral bacterial co-infection of the respiratory tract during early childhood. FEMS Microbiol Lett 2015; 362(10): fnv062.
5. Bashir H, Grindle K, Vrtis R, et al. Association of rhinovirus species with common cold and asthma symptoms and bacterial pathogens. J Allergy Clin Immunol 2018; 141(2): 822–824.e9.
6. Meissner HC. Viral bronchiolitis in children. N Engl J Med 2016; 374(1): 62–72.
7. Steinberg BE, Goldenberg NM, Lee WL. Do viral infections mimic bacterial sepsis? The role of microvascular permeability: A review of mechanisms and methods. Antiviral Res 2012; 93(1): 2–15.
8. Schuster JE, Williams JV. Emerging respiratory viruses in children. Infect Dis Clin North Am 2018; 32(1): 65–74.
9. Spacova I, Boeck ID, Bron PA, et al. Topical microbial therapeutics against respiratory viral infections. Trends Mol Med 2021; 27(6): 538–53.
10. Achten NB, Wu P, Bont L, et al. Interference between respiratory syncytial virus and human rhinovirus infection in infancy. J Infect Dis 2017; 215(7): 1102–6.
11. Rossi GA, Colin AA. Infantile respiratory syncytial virus and human rhinovirus infections: respective role in inception and persistence of wheezing. Eur Respir J 2015; 45(3): 774–89.
12. Lei C, Yang L, Lou CT, et al. Viral etiology and epidemiology of pediatric patients hospitalized for acute respiratory tract infections in Macao: a retrospective study from 2014 to 2017. BMC Infect Dis 2021; 21(1): 306.
13. Núñez-Samudio V, Landires I. Epidemiology of viral respiratory infections in a pediatric reference hospital in Central Panama. BMC Infect Dis 2021; 21(1): 43.
14. Wang H, Zheng Y, Deng J, et al. Prevalence of respiratory viruses among children hospitalized from respiratory infections in Shenzhen, China. Virol J 2016; 13(1): 39.
15. Messacar K, Robinson CC, Bagdure D, et al. Rhino/enteroviruses in hospitalized children: A comparison to influenza viruses. J Clin Virol 2013; 56(1): 41–5.
16. Spaeder MC, Custer JW, Miles AH, et al. A multicenter outcomes analysis of children with severe rhino/enteroviral respiratory infection. Pediatr Crit Care Med 2015; 16(2): 119.
17. Lopes GP, Amorim ÍPS, Melo B de O de, et al. Identification and seasonality of rhinovirus and respiratory syncytial virus in asthmatic children in tropical climate. Biosci Rep 2020; 40(9): BSR20200634.
18. Karppinen S, Toivonen L, Schuez-Havupalo L, et al. Interference between respiratory syncytial virus and rhinovirus in respiratory tract infections in children. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis 2016; 22(2): 208.e1–208.e6.
19. Hubáček P, Smíšková D. Infekce vyvolané respiračními syncytiálními viry - epidemiologie, klinický obraz, diagnostika, možnosti prevence a léčby. Čes-Slov Pediatr 2023; 78(Suppl.1): 13–9.
20. Makrinioti H, Hasegawa K, Lakoumentas J, et al. The role of respiratory syncytial virus- and rhinovirus-induced bronchiolitis in recurrent wheeze and asthma-A systematic review and meta-analysis. Pediatr Allergy Immunol Off Publ Eur Soc Pediatr Allergy Immunol 2022; 33(3): e13741.
21. Hamad AF, Yan L, Jafari Jozani M, et al. Developing a prediction model of children asthma risk using population-based family history health records. Pediatr Allergy Immunol 2023; 34(10): e14032.
22. Moriyama M, Hugentobler WJ, Iwasaki A. Seasonality of respiratory viral infections. Annu Rev Virol 2020; 7(1): 83–101.
Štítky
Neonatology Paediatrics General practitioner for children and adolescentsČlánok vyšiel v časopise
Czech-Slovak Pediatrics
2024 Číslo 5
- What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?
- The Importance of Limosilactobacillus reuteri in Administration to Diabetics with Gingivitis
Najčítanejšie v tomto čísle
- Inherited disorders of lipid metabolism (lipoproteins, fatty acids, cholesterol and sphingolipids)
- Epidemiological aspects of selected respiratory viruses in children with recurrent respiratory infections
- Emergence delirium in children: up to date for pediatricians