Epidermolytic hyperkeratosis of the vulva associated with basal cell carcinoma in a patient with vaginal condyloma acuminatum and vaginal intraepithelial neoplasia harboring HPV, type 42

Česká verzia

Authors: Denisa Kacerovská ^1,2; Michal Michal ^1,2 ; Jana Kašpírková ²; Dmitry V. Kazakov ^1,2
Authors place of work: Šikl’s Department of Pathology, Charles University in Prague, Faculty of Medicine in Pilsen, Pilsen, Czech Republic ¹; Bioptic Laboratory, Pilsen, Czech Republic ²
Published in the journal: Čes.-slov. Patol., 50, 2014, No. 2, p. 92-94
Category: Original Article

Summary

The occurrence of basal cell carcinoma (BCC) of the vulva is rare. We report the case of a 79-year-old woman with a medical history of intravaginal condyloma acuminatum and vaginal intraepithelial neoplasia 3 (VaIN 3) who presented with a solitary whitish lesion sized 8x5 mm with a central desquamation located on the right labium majus. Histopathologic examination revealed a typical superficial and nodular BCC. Additionally, there were multiple remarkable foci of epidermolytic hyperkeratosis (EH). These foci both merged with superficial BCC or were sharply demarcated from the tumor. Retrospective molecular-biological examination of all the available material revealed HPV type 42 in both condyloma acuminatum and VaIN 3 specimen but not in the BCC associated with EH. To our best knowledge, involvement of the lower female genitalia by EH is a rare finding with six cases published to date. Awareness of EH in this location and its distinction is important because it may be potentially misinterpreted as a viral condyloma.

Keywords:
vulva – basal cell carcinoma – epidermolytic hyperkeratosis – human papillomavirus

Zdroje

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