Hydatidiform mole

Česká verzia

Authors: Magdaléna Daumová ^1,2; Šárka Hadravská ^1,2; Martina Putzová ²
Authors place of work: Šiklův ústav patologie LFP UK a FN Plzeň ¹; Bioptická laboratoř s. r. o., Plzeň ²
Published in the journal: Čes.-slov. Patol., 59, 2023, No. 2, p. 50-54
Category: Reviews Article

Summary

Hydatidiform mole is the most common form of gestational trophoblastic disease. It is an abnormally formed placental tissue with characteristic changes in karyotype, arising in fertilization disorders. The presence of abundant paternal genetic information plays a key role in the pathogenesis of complete and partial hydatidiform moles. These lesions are characterized by a relatively wide spectrum of morphological changes that may not be fully expressed, especially in the early stages of pregnancy. In addition, some changes can be observed in non-molar gravidities, which, unlike hydatidiform moles, lack any risk of malignant transformation. Although conventional histological examination still plays a key role in the diagnosis, it should be supplemented by other methods that reliably differentiate individual lesions. Accurate diagnosis of molar gravidities is important not only for determining the correct therapeutic approach, but the obtained data may also contribute to further research of these pathological entities.

Keywords:

molecular genetic testing – Triploidy – Genomic imprinting – p57 – gestational trophoblastic disease – hydatidiform mole – CHM – PHM

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